SPECT/CT imaging of hNIS-expression after intravenous delivery of an oncolytic adenovirus and 131I.

Oncolytic adenoviruses can be engineered for better tumor selectivity, gene delivery and be armed for imaging and concentrating radionuclides into tumors for synergistic oncolysis. We constructed Ad5/3-hTERT-hNIS where replication is controlled by hTERT-promoter. Ad5/3-hTERT-hNIS expresses hNIS for...

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Autores principales: Maria Rajecki, Mirkka Sarparanta, Tanja Hakkarainen, Mikko Tenhunen, Iulia Diaconu, Venla Kuhmonen, Kalevi Kairemo, Anna Kanerva, Anu J Airaksinen, Akseli Hemminki
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/e17cf8fdf1f44f05a7bd565386ab942e
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