Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
Activation of the NLRP3 inflammasome triggers the production of inflammatory cytokines. Here, the authors inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and show that administration in mice is effective in preventing septic shock and peritonitis, and in improving di...
Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2018
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/e182709484b64fe19f545ff4ce50c591 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|