Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

Activation of the NLRP3 inflammasome triggers the production of inflammatory cytokines. Here, the authors inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and show that administration in mice is effective in preventing septic shock and peritonitis, and in improving di...

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Autores principales:	Congfei Xu, Zidong Lu, Yingli Luo, Yang Liu, Zhiting Cao, Song Shen, Hongjun Li, Jing Liu, Kaige Chen, Zhiyao Chen, Xianzhu Yang, Zhen Gu, Jun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e182709484b64fe19f545ff4ce50c591
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spelling	oai:doaj.org-article:e182709484b64fe19f545ff4ce50c5912021-12-02T17:32:34ZTargeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases10.1038/s41467-018-06522-52041-1723https://doaj.org/article/e182709484b64fe19f545ff4ce50c5912018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06522-5https://doaj.org/toc/2041-1723Activation of the NLRP3 inflammasome triggers the production of inflammatory cytokines. Here, the authors inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and show that administration in mice is effective in preventing septic shock and peritonitis, and in improving diabetes-associated inflammation and insulin resistance.Congfei XuZidong LuYingli LuoYang LiuZhiting CaoSong ShenHongjun LiJing LiuKaige ChenZhiyao ChenXianzhu YangZhen GuJun WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Congfei Xu Zidong Lu Yingli Luo Yang Liu Zhiting Cao Song Shen Hongjun Li Jing Liu Kaige Chen Zhiyao Chen Xianzhu Yang Zhen Gu Jun Wang Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
description	Activation of the NLRP3 inflammasome triggers the production of inflammatory cytokines. Here, the authors inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and show that administration in mice is effective in preventing septic shock and peritonitis, and in improving diabetes-associated inflammation and insulin resistance.
format	article
author	Congfei Xu Zidong Lu Yingli Luo Yang Liu Zhiting Cao Song Shen Hongjun Li Jing Liu Kaige Chen Zhiyao Chen Xianzhu Yang Zhen Gu Jun Wang
author_facet	Congfei Xu Zidong Lu Yingli Luo Yang Liu Zhiting Cao Song Shen Hongjun Li Jing Liu Kaige Chen Zhiyao Chen Xianzhu Yang Zhen Gu Jun Wang
author_sort	Congfei Xu
title	Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
title_short	Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
title_full	Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
title_fullStr	Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
title_full_unstemmed	Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
title_sort	targeting of nlrp3 inflammasome with gene editing for the amelioration of inflammatory diseases
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e182709484b64fe19f545ff4ce50c591
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Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

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