Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

Activation of the NLRP3 inflammasome triggers the production of inflammatory cytokines. Here, the authors inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and show that administration in mice is effective in preventing septic shock and peritonitis, and in improving di...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Congfei Xu, Zidong Lu, Yingli Luo, Yang Liu, Zhiting Cao, Song Shen, Hongjun Li, Jing Liu, Kaige Chen, Zhiyao Chen, Xianzhu Yang, Zhen Gu, Jun Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e182709484b64fe19f545ff4ce50c591
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares