HEPATIC SOD1 GENE EXPRESSION CHANGES IN THE NAFLD PATHOGENESIS IN OBESITY

Steatosis in the liver in obesity increases the work of mitochondria to utilize excess lipids. An overload of β-oxidation of fatty acids, the tricarboxylic acid cycle, and oxidative phosphorylation leads to a decrease in ATP and an increase in the formation of reactive oxygen species. Normally, mito...

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Autores principales:	A. A. Komar, D. A. Shunkina (Skuratovsvkaia), M. A. Vulf, H. Q. Vu, N. M. Todosenko, P. A. Zatolokin, E. V. Kirienkova, N. D. Gazatova, L. S. Litvinova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	obesity t2dm superoxide dismutase mtdna liver steatosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e1851aa1076b4b299bd68be2c8bc8d4b
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spelling	oai:doaj.org-article:e1851aa1076b4b299bd68be2c8bc8d4b2021-11-18T08:03:51ZHEPATIC SOD1 GENE EXPRESSION CHANGES IN THE NAFLD PATHOGENESIS IN OBESITY1563-06252313-741X10.15789/1563-0625-HSG-2282https://doaj.org/article/e1851aa1076b4b299bd68be2c8bc8d4b2021-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2282https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XSteatosis in the liver in obesity increases the work of mitochondria to utilize excess lipids. An overload of β-oxidation of fatty acids, the tricarboxylic acid cycle, and oxidative phosphorylation leads to a decrease in ATP and an increase in the formation of reactive oxygen species. Normally, mitochondria can efficiently remove elevated levels of reactive oxygen species using the cell's antioxidant system and metabolic adaptation to altered conditions. This study aimed to investigate the role of hepatic SOD expression in the pathogenesis of NAFLD in obesity. It was found that the level of SOD1 expression in the liver in obese patients with and without type 2 diabetes with a BMI > 40 kg/m2 was lower than in healthy donors. The copy number of mitochondrial DNA (mtDNA) in the liver in all obese patients was more than two times lower than in the control group. In the liver of obese patients without type 2 diabetes, the SOD1 protein level and the mtDNA copy number were interrelated and negatively correlated with the area of fatty inclusions. Thus, in obese patients, a decrease in antioxidant defense in the liver leads to the vulnerability of mitochondria, which, in turn, contributes to the progression of steatosis and insulin resistance.A. A. KomarD. A. Shunkina (Skuratovsvkaia)M. A. VulfH. Q. VuN. M. TodosenkoP. A. ZatolokinE. V. KirienkovaN. D. GazatovaL. S. LitvinovaSPb RAACIarticleobesityt2dmsuperoxide dismutasemtdnaliversteatosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 4, Pp 761-766 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	obesity t2dm superoxide dismutase mtdna liver steatosis Immunologic diseases. Allergy RC581-607
spellingShingle	obesity t2dm superoxide dismutase mtdna liver steatosis Immunologic diseases. Allergy RC581-607 A. A. Komar D. A. Shunkina (Skuratovsvkaia) M. A. Vulf H. Q. Vu N. M. Todosenko P. A. Zatolokin E. V. Kirienkova N. D. Gazatova L. S. Litvinova HEPATIC SOD1 GENE EXPRESSION CHANGES IN THE NAFLD PATHOGENESIS IN OBESITY
description	Steatosis in the liver in obesity increases the work of mitochondria to utilize excess lipids. An overload of β-oxidation of fatty acids, the tricarboxylic acid cycle, and oxidative phosphorylation leads to a decrease in ATP and an increase in the formation of reactive oxygen species. Normally, mitochondria can efficiently remove elevated levels of reactive oxygen species using the cell's antioxidant system and metabolic adaptation to altered conditions. This study aimed to investigate the role of hepatic SOD expression in the pathogenesis of NAFLD in obesity. It was found that the level of SOD1 expression in the liver in obese patients with and without type 2 diabetes with a BMI > 40 kg/m2 was lower than in healthy donors. The copy number of mitochondrial DNA (mtDNA) in the liver in all obese patients was more than two times lower than in the control group. In the liver of obese patients without type 2 diabetes, the SOD1 protein level and the mtDNA copy number were interrelated and negatively correlated with the area of fatty inclusions. Thus, in obese patients, a decrease in antioxidant defense in the liver leads to the vulnerability of mitochondria, which, in turn, contributes to the progression of steatosis and insulin resistance.
format	article
author	A. A. Komar D. A. Shunkina (Skuratovsvkaia) M. A. Vulf H. Q. Vu N. M. Todosenko P. A. Zatolokin E. V. Kirienkova N. D. Gazatova L. S. Litvinova
author_facet	A. A. Komar D. A. Shunkina (Skuratovsvkaia) M. A. Vulf H. Q. Vu N. M. Todosenko P. A. Zatolokin E. V. Kirienkova N. D. Gazatova L. S. Litvinova
author_sort	A. A. Komar
title	HEPATIC SOD1 GENE EXPRESSION CHANGES IN THE NAFLD PATHOGENESIS IN OBESITY
title_short	HEPATIC SOD1 GENE EXPRESSION CHANGES IN THE NAFLD PATHOGENESIS IN OBESITY
title_full	HEPATIC SOD1 GENE EXPRESSION CHANGES IN THE NAFLD PATHOGENESIS IN OBESITY
title_fullStr	HEPATIC SOD1 GENE EXPRESSION CHANGES IN THE NAFLD PATHOGENESIS IN OBESITY
title_full_unstemmed	HEPATIC SOD1 GENE EXPRESSION CHANGES IN THE NAFLD PATHOGENESIS IN OBESITY
title_sort	hepatic sod1 gene expression changes in the nafld pathogenesis in obesity
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/e1851aa1076b4b299bd68be2c8bc8d4b
work_keys_str_mv	AT aakomar hepaticsod1geneexpressionchangesinthenafldpathogenesisinobesity AT dashunkinaskuratovsvkaia hepaticsod1geneexpressionchangesinthenafldpathogenesisinobesity AT mavulf hepaticsod1geneexpressionchangesinthenafldpathogenesisinobesity AT hqvu hepaticsod1geneexpressionchangesinthenafldpathogenesisinobesity AT nmtodosenko hepaticsod1geneexpressionchangesinthenafldpathogenesisinobesity AT pazatolokin hepaticsod1geneexpressionchangesinthenafldpathogenesisinobesity AT evkirienkova hepaticsod1geneexpressionchangesinthenafldpathogenesisinobesity AT ndgazatova hepaticsod1geneexpressionchangesinthenafldpathogenesisinobesity AT lslitvinova hepaticsod1geneexpressionchangesinthenafldpathogenesisinobesity
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HEPATIC SOD1 GENE EXPRESSION CHANGES IN THE NAFLD PATHOGENESIS IN OBESITY

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