Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive malignancy characterised by the presence of extensive desmoplasia, thought to be responsible for the poor response of patients to systemic therapies. Pancreatic stellate cells (PSCs) are key mediators in the production of this fibroti...

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Autores principales: Dariusz Lachowski, Ernesto Cortes, Daniel Pink, Antonios Chronopoulos, Saadia A. Karim, Jennifer P. Morton, Armando E. del Río Hernández
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e193b1e2c92148c1a09cd72152baee26
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