Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity

Patient-specific precision medicine approaches are important for future cancer therapies. Here, the authors show that functional drug profiling with Rhabdomyosarcoma cells isolated from PDX and primary patient tumors uncovers patient-specific vulnerabilities.

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Autores principales:	Gabriele Manzella, Leonie D. Schreck, Willemijn B. Breunis, Jan Molenaar, Hans Merks, Frederic G. Barr, Wenyue Sun, Michaela Römmele, Luduo Zhang, Joelle Tchinda, Quy A. Ngo, Peter Bode, Olivier Delattre, Didier Surdez, Bharat Rekhi, Felix K. Niggli, Beat W. Schäfer, Marco Wachtel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1a776112ff34407a13275f886ecd3a9
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spelling	oai:doaj.org-article:e1a776112ff34407a13275f886ecd3a92021-12-02T15:15:59ZPhenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity10.1038/s41467-020-18388-72041-1723https://doaj.org/article/e1a776112ff34407a13275f886ecd3a92020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18388-7https://doaj.org/toc/2041-1723Patient-specific precision medicine approaches are important for future cancer therapies. Here, the authors show that functional drug profiling with Rhabdomyosarcoma cells isolated from PDX and primary patient tumors uncovers patient-specific vulnerabilities.Gabriele ManzellaLeonie D. SchreckWillemijn B. BreunisJan MolenaarHans MerksFrederic G. BarrWenyue SunMichaela RömmeleLuduo ZhangJoelle TchindaQuy A. NgoPeter BodeOlivier DelattreDidier SurdezBharat RekhiFelix K. NiggliBeat W. SchäferMarco WachtelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriele Manzella Leonie D. Schreck Willemijn B. Breunis Jan Molenaar Hans Merks Frederic G. Barr Wenyue Sun Michaela Römmele Luduo Zhang Joelle Tchinda Quy A. Ngo Peter Bode Olivier Delattre Didier Surdez Bharat Rekhi Felix K. Niggli Beat W. Schäfer Marco Wachtel Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
description	Patient-specific precision medicine approaches are important for future cancer therapies. Here, the authors show that functional drug profiling with Rhabdomyosarcoma cells isolated from PDX and primary patient tumors uncovers patient-specific vulnerabilities.
format	article
author	Gabriele Manzella Leonie D. Schreck Willemijn B. Breunis Jan Molenaar Hans Merks Frederic G. Barr Wenyue Sun Michaela Römmele Luduo Zhang Joelle Tchinda Quy A. Ngo Peter Bode Olivier Delattre Didier Surdez Bharat Rekhi Felix K. Niggli Beat W. Schäfer Marco Wachtel
author_facet	Gabriele Manzella Leonie D. Schreck Willemijn B. Breunis Jan Molenaar Hans Merks Frederic G. Barr Wenyue Sun Michaela Römmele Luduo Zhang Joelle Tchinda Quy A. Ngo Peter Bode Olivier Delattre Didier Surdez Bharat Rekhi Felix K. Niggli Beat W. Schäfer Marco Wachtel
author_sort	Gabriele Manzella
title	Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
title_short	Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
title_full	Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
title_fullStr	Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
title_full_unstemmed	Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
title_sort	phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and akt sensitivity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e1a776112ff34407a13275f886ecd3a9
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Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity

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