Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging
Epigenetic silencing of Lgr5 in aged organoids To understand the molecular features underlying stem cell aging, we established intestinal epithelial organoids derived from both young and aged mice, and investigated alterations in their senescence and epigenetic status. Senescence-related changes inc...
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| Main Authors: | , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2018
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| Subjects: | |
| Online Access: | https://doaj.org/article/e1c53da2776440f3a69b4e2f9cf4edf3 |
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