Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters

Bobo Wing-Yee Mok et al. observe that the Alpha (B.1.1.7) variant of SARS-CoV-2 exhibits increased competitive fitness over earlier lineages at lower doses in a hamster model of viral transmission. Their results suggest that the Alpha variant’s ability to initiate effective infection with a low dose...

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Autores principales:	Bobo Wing-Yee Mok, Honglian Liu, Shaofeng Deng, Jiayan Liu, Anna Jinxia Zhang, Siu-Ying Lau, Siwen Liu, Rachel Chun-Yee Tam, Conor J. Cremin, Timothy Ting-Leung Ng, Jake Siu-Lun Leung, Lam-Kwong Lee, Pui Wang, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, Kwok-Hung Chan, Kwok-Yung Yuen, Gilman Kit-Hang Siu, Honglin Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e1d11d48a5164a96b5e36a1d1ccb137f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:e1d11d48a5164a96b5e36a1d1ccb137f2021-12-02T17:26:48ZLow dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters10.1038/s42003-021-02640-x2399-3642https://doaj.org/article/e1d11d48a5164a96b5e36a1d1ccb137f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02640-xhttps://doaj.org/toc/2399-3642Bobo Wing-Yee Mok et al. observe that the Alpha (B.1.1.7) variant of SARS-CoV-2 exhibits increased competitive fitness over earlier lineages at lower doses in a hamster model of viral transmission. Their results suggest that the Alpha variant’s ability to initiate effective infection with a low dose may underlie its ability to rapidly transmit throughout a population.Bobo Wing-Yee MokHonglian LiuShaofeng DengJiayan LiuAnna Jinxia ZhangSiu-Ying LauSiwen LiuRachel Chun-Yee TamConor J. CreminTimothy Ting-Leung NgJake Siu-Lun LeungLam-Kwong LeePui WangKelvin Kai-Wang ToJasper Fuk-Woo ChanKwok-Hung ChanKwok-Yung YuenGilman Kit-Hang SiuHonglin ChenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Bobo Wing-Yee Mok Honglian Liu Shaofeng Deng Jiayan Liu Anna Jinxia Zhang Siu-Ying Lau Siwen Liu Rachel Chun-Yee Tam Conor J. Cremin Timothy Ting-Leung Ng Jake Siu-Lun Leung Lam-Kwong Lee Pui Wang Kelvin Kai-Wang To Jasper Fuk-Woo Chan Kwok-Hung Chan Kwok-Yung Yuen Gilman Kit-Hang Siu Honglin Chen Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters
description	Bobo Wing-Yee Mok et al. observe that the Alpha (B.1.1.7) variant of SARS-CoV-2 exhibits increased competitive fitness over earlier lineages at lower doses in a hamster model of viral transmission. Their results suggest that the Alpha variant’s ability to initiate effective infection with a low dose may underlie its ability to rapidly transmit throughout a population.
format	article
author	Bobo Wing-Yee Mok Honglian Liu Shaofeng Deng Jiayan Liu Anna Jinxia Zhang Siu-Ying Lau Siwen Liu Rachel Chun-Yee Tam Conor J. Cremin Timothy Ting-Leung Ng Jake Siu-Lun Leung Lam-Kwong Lee Pui Wang Kelvin Kai-Wang To Jasper Fuk-Woo Chan Kwok-Hung Chan Kwok-Yung Yuen Gilman Kit-Hang Siu Honglin Chen
author_facet	Bobo Wing-Yee Mok Honglian Liu Shaofeng Deng Jiayan Liu Anna Jinxia Zhang Siu-Ying Lau Siwen Liu Rachel Chun-Yee Tam Conor J. Cremin Timothy Ting-Leung Ng Jake Siu-Lun Leung Lam-Kwong Lee Pui Wang Kelvin Kai-Wang To Jasper Fuk-Woo Chan Kwok-Hung Chan Kwok-Yung Yuen Gilman Kit-Hang Siu Honglin Chen
author_sort	Bobo Wing-Yee Mok
title	Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters
title_short	Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters
title_full	Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters
title_fullStr	Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters
title_full_unstemmed	Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters
title_sort	low dose inocula of sars-cov-2 alpha variant transmits more efficiently than earlier variants in hamsters
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e1d11d48a5164a96b5e36a1d1ccb137f
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Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters

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