Proximal GATA-binding sites are essential for human HSD3B1 gene transcription in the placenta

Abstract The enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is involved in the synthesis of active steroid hormones. Two human 3β-HSD isoforms are expressed in a tissue-specific pattern. HSD3B1 (type I) expression is essential to produce progesterone for pregnancy maintenance. To understa...

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Autores principales: Tsai-Chun Lai, Hsiao-Fang Li, Yu-Shian Li, Pei-Yu Hung, Ming-Kwang Shyu, Meng-Chun Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e1f23b51de7445fcae7c171b16fdaee1
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