Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps

Acute pancreatitis is a serious inflammatory disease, which is more severe in diabetic mice. Here the authors use mice lacking pancreatic acinar cell insulin receptors to show that this may be because insulin preserves glycolytic energy supply in acinar cell during pancreatitis, which prevents cytot...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jason I. E. Bruce, Rosa Sánchez-Alvarez, Maria Dolors Sans, Sarah A. Sugden, Nathan Qi, Andrew D. James, John A. Williams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e209eb1710b64e959c279b5186b0a3a7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e209eb1710b64e959c279b5186b0a3a7
record_format	dspace
spelling	oai:doaj.org-article:e209eb1710b64e959c279b5186b0a3a72021-12-02T16:17:53ZInsulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps10.1038/s41467-021-24506-w2041-1723https://doaj.org/article/e209eb1710b64e959c279b5186b0a3a72021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24506-whttps://doaj.org/toc/2041-1723Acute pancreatitis is a serious inflammatory disease, which is more severe in diabetic mice. Here the authors use mice lacking pancreatic acinar cell insulin receptors to show that this may be because insulin preserves glycolytic energy supply in acinar cell during pancreatitis, which prevents cytotoxic calcium overload and cell death.Jason I. E. BruceRosa Sánchez-AlvarezMaria Dolors SansSarah A. SugdenNathan QiAndrew D. JamesJohn A. WilliamsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason I. E. Bruce Rosa Sánchez-Alvarez Maria Dolors Sans Sarah A. Sugden Nathan Qi Andrew D. James John A. Williams Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps
description	Acute pancreatitis is a serious inflammatory disease, which is more severe in diabetic mice. Here the authors use mice lacking pancreatic acinar cell insulin receptors to show that this may be because insulin preserves glycolytic energy supply in acinar cell during pancreatitis, which prevents cytotoxic calcium overload and cell death.
format	article
author	Jason I. E. Bruce Rosa Sánchez-Alvarez Maria Dolors Sans Sarah A. Sugden Nathan Qi Andrew D. James John A. Williams
author_facet	Jason I. E. Bruce Rosa Sánchez-Alvarez Maria Dolors Sans Sarah A. Sugden Nathan Qi Andrew D. James John A. Williams
author_sort	Jason I. E. Bruce
title	Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps
title_short	Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps
title_full	Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps
title_fullStr	Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps
title_full_unstemmed	Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps
title_sort	insulin protects acinar cells during pancreatitis by preserving glycolytic atp supply to calcium pumps
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e209eb1710b64e959c279b5186b0a3a7
work_keys_str_mv	AT jasoniebruce insulinprotectsacinarcellsduringpancreatitisbypreservingglycolyticatpsupplytocalciumpumps AT rosasanchezalvarez insulinprotectsacinarcellsduringpancreatitisbypreservingglycolyticatpsupplytocalciumpumps AT mariadolorssans insulinprotectsacinarcellsduringpancreatitisbypreservingglycolyticatpsupplytocalciumpumps AT sarahasugden insulinprotectsacinarcellsduringpancreatitisbypreservingglycolyticatpsupplytocalciumpumps AT nathanqi insulinprotectsacinarcellsduringpancreatitisbypreservingglycolyticatpsupplytocalciumpumps AT andrewdjames insulinprotectsacinarcellsduringpancreatitisbypreservingglycolyticatpsupplytocalciumpumps AT johnawilliams insulinprotectsacinarcellsduringpancreatitisbypreservingglycolyticatpsupplytocalciumpumps
_version_	1718384263390298112

Insulin protects acinar cells during pancreatitis by preserving glycolytic ATP supply to calcium pumps

Ejemplares similares