Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

Cancer stem cells are thought to be largely resistant to treatment and can be responsible for tumour recurrence. Here, using renal cancer organoids, self-renewing sphere cultures and PDX from patients, the authors show that the proliferation of stem cells within organoids, PDX and spheres can be blo...

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Autores principales: Annika Fendler, Daniel Bauer, Jonas Busch, Klaus Jung, Annika Wulf-Goldenberg, Severine Kunz, Kun Song, Adam Myszczyszyn, Sefer Elezkurtaj, Bettina Erguen, Simone Jung, Wei Chen, Walter Birchmeier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e20e23a96a924161a7b8a3b6741f03e9
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