Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

Cancer stem cells are thought to be largely resistant to treatment and can be responsible for tumour recurrence. Here, using renal cancer organoids, self-renewing sphere cultures and PDX from patients, the authors show that the proliferation of stem cells within organoids, PDX and spheres can be blo...

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Autores principales:	Annika Fendler, Daniel Bauer, Jonas Busch, Klaus Jung, Annika Wulf-Goldenberg, Severine Kunz, Kun Song, Adam Myszczyszyn, Sefer Elezkurtaj, Bettina Erguen, Simone Jung, Wei Chen, Walter Birchmeier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e20e23a96a924161a7b8a3b6741f03e9
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spelling	oai:doaj.org-article:e20e23a96a924161a7b8a3b6741f03e92021-12-02T17:33:15ZInhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients10.1038/s41467-020-14700-72041-1723https://doaj.org/article/e20e23a96a924161a7b8a3b6741f03e92020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14700-7https://doaj.org/toc/2041-1723Cancer stem cells are thought to be largely resistant to treatment and can be responsible for tumour recurrence. Here, using renal cancer organoids, self-renewing sphere cultures and PDX from patients, the authors show that the proliferation of stem cells within organoids, PDX and spheres can be blocked by the concomitant inhibition of the NOTCH and WNT pathways.Annika FendlerDaniel BauerJonas BuschKlaus JungAnnika Wulf-GoldenbergSeverine KunzKun SongAdam MyszczyszynSefer ElezkurtajBettina ErguenSimone JungWei ChenWalter BirchmeierNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Annika Fendler Daniel Bauer Jonas Busch Klaus Jung Annika Wulf-Goldenberg Severine Kunz Kun Song Adam Myszczyszyn Sefer Elezkurtaj Bettina Erguen Simone Jung Wei Chen Walter Birchmeier Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
description	Cancer stem cells are thought to be largely resistant to treatment and can be responsible for tumour recurrence. Here, using renal cancer organoids, self-renewing sphere cultures and PDX from patients, the authors show that the proliferation of stem cells within organoids, PDX and spheres can be blocked by the concomitant inhibition of the NOTCH and WNT pathways.
format	article
author	Annika Fendler Daniel Bauer Jonas Busch Klaus Jung Annika Wulf-Goldenberg Severine Kunz Kun Song Adam Myszczyszyn Sefer Elezkurtaj Bettina Erguen Simone Jung Wei Chen Walter Birchmeier
author_facet	Annika Fendler Daniel Bauer Jonas Busch Klaus Jung Annika Wulf-Goldenberg Severine Kunz Kun Song Adam Myszczyszyn Sefer Elezkurtaj Bettina Erguen Simone Jung Wei Chen Walter Birchmeier
author_sort	Annika Fendler
title	Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
title_short	Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
title_full	Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
title_fullStr	Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
title_full_unstemmed	Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients
title_sort	inhibiting wnt and notch in renal cancer stem cells and the implications for human patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e20e23a96a924161a7b8a3b6741f03e9
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Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

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