Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells
Abstract The definition of the immunological response to Zika (ZIKV) infection in humans represents a key issue to identify protective profile useful for vaccine development and for pathogenesis studies. No data are available on the cellular immune response in the acute phase of human ZIKV infection...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/e211ed0897014f748616b1a30cb3342e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:e211ed0897014f748616b1a30cb3342e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:e211ed0897014f748616b1a30cb3342e2021-12-02T16:07:59ZHuman Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells10.1038/s41598-017-06536-x2045-2322https://doaj.org/article/e211ed0897014f748616b1a30cb3342e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06536-xhttps://doaj.org/toc/2045-2322Abstract The definition of the immunological response to Zika (ZIKV) infection in humans represents a key issue to identify protective profile useful for vaccine development and for pathogenesis studies. No data are available on the cellular immune response in the acute phase of human ZIKV infection, and its role in the protection and/or pathogenesis needs to be clarified. We studied and compared the phenotype and functionality of T-cells in patients with acute ZIKV and Dengue viral (DENV) infections. A significant activation of T-cells was observed during both ZIKV and DENV infections. ZIKV infection was characterized by a CD4 T cell differentiation toward effector cells and by a lower frequency of IFN-γ producing CD4 T cells. Moreover, a substantial expansion of CD3+CD4−CD8− T-cell subset expressing Vδ2 TCR was specifically observed in ZIKV patients. Vδ2 T cells presented a terminally differentiated profile, expressed granzyme B and maintained their ability to produce IFN-γ. These findings provide new knowledge on the immune response profile during self-limited infection that may help in vaccine efficacy definition, and in identifying possible immuno-pathogenetic mechanisms of severe infection.Eleonora CiminiConcetta CastillettiAlessandra SacchiRita CasettiVeronica BordoniAntonella RomanelliFederica TurchiFederico MartiniNicola TuminoEmanuele NicastriAngela CorpolongoAntonino Di CaroGary KobingerAlimuddin ZumlaMaria Rosaria CapobianchiGiuseppe IppolitoChiara AgratiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Eleonora Cimini Concetta Castilletti Alessandra Sacchi Rita Casetti Veronica Bordoni Antonella Romanelli Federica Turchi Federico Martini Nicola Tumino Emanuele Nicastri Angela Corpolongo Antonino Di Caro Gary Kobinger Alimuddin Zumla Maria Rosaria Capobianchi Giuseppe Ippolito Chiara Agrati Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells |
| description |
Abstract The definition of the immunological response to Zika (ZIKV) infection in humans represents a key issue to identify protective profile useful for vaccine development and for pathogenesis studies. No data are available on the cellular immune response in the acute phase of human ZIKV infection, and its role in the protection and/or pathogenesis needs to be clarified. We studied and compared the phenotype and functionality of T-cells in patients with acute ZIKV and Dengue viral (DENV) infections. A significant activation of T-cells was observed during both ZIKV and DENV infections. ZIKV infection was characterized by a CD4 T cell differentiation toward effector cells and by a lower frequency of IFN-γ producing CD4 T cells. Moreover, a substantial expansion of CD3+CD4−CD8− T-cell subset expressing Vδ2 TCR was specifically observed in ZIKV patients. Vδ2 T cells presented a terminally differentiated profile, expressed granzyme B and maintained their ability to produce IFN-γ. These findings provide new knowledge on the immune response profile during self-limited infection that may help in vaccine efficacy definition, and in identifying possible immuno-pathogenetic mechanisms of severe infection. |
| format |
article |
| author |
Eleonora Cimini Concetta Castilletti Alessandra Sacchi Rita Casetti Veronica Bordoni Antonella Romanelli Federica Turchi Federico Martini Nicola Tumino Emanuele Nicastri Angela Corpolongo Antonino Di Caro Gary Kobinger Alimuddin Zumla Maria Rosaria Capobianchi Giuseppe Ippolito Chiara Agrati |
| author_facet |
Eleonora Cimini Concetta Castilletti Alessandra Sacchi Rita Casetti Veronica Bordoni Antonella Romanelli Federica Turchi Federico Martini Nicola Tumino Emanuele Nicastri Angela Corpolongo Antonino Di Caro Gary Kobinger Alimuddin Zumla Maria Rosaria Capobianchi Giuseppe Ippolito Chiara Agrati |
| author_sort |
Eleonora Cimini |
| title |
Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells |
| title_short |
Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells |
| title_full |
Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells |
| title_fullStr |
Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells |
| title_full_unstemmed |
Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells |
| title_sort |
human zika infection induces a reduction of ifn-γ producing cd4 t-cells and a parallel expansion of effector vδ2 t-cells |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/e211ed0897014f748616b1a30cb3342e |
| work_keys_str_mv |
AT eleonoracimini humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT concettacastilletti humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT alessandrasacchi humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT ritacasetti humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT veronicabordoni humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT antonellaromanelli humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT federicaturchi humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT federicomartini humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT nicolatumino humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT emanuelenicastri humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT angelacorpolongo humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT antoninodicaro humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT garykobinger humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT alimuddinzumla humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT mariarosariacapobianchi humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT giuseppeippolito humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells AT chiaraagrati humanzikainfectioninducesareductionofifngproducingcd4tcellsandaparallelexpansionofeffectorvd2tcells |
| _version_ |
1718384688893001728 |