A phosphotyrosine switch regulates organic cation transporters
Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug transporter function through post-translational mec...
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/e23f1634f35944d0a0ca31c8bfbcf90b |
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oai:doaj.org-article:e23f1634f35944d0a0ca31c8bfbcf90b2021-12-02T16:56:46ZA phosphotyrosine switch regulates organic cation transporters10.1038/ncomms108802041-1723https://doaj.org/article/e23f1634f35944d0a0ca31c8bfbcf90b2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10880https://doaj.org/toc/2041-1723Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug transporter function through post-translational mechanisms.Jason A. SprowlSu Sien OngAlice A. GibsonShuiying HuGuoqing DuWenwei LinLie LiShashank BharillRachel A. NessAdrian SteculaSteven M. OfferRobert B. DiasioAnne T. NiesMatthias SchwabGuido CavalettiEberhard SchlatterGiuliano CiarimboliJan H. M. SchellensEhud Y. IsacoffAndrej SaliTaosheng ChenSharyn D. BakerAlex SparreboomNavjotsingh PablaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jason A. Sprowl Su Sien Ong Alice A. Gibson Shuiying Hu Guoqing Du Wenwei Lin Lie Li Shashank Bharill Rachel A. Ness Adrian Stecula Steven M. Offer Robert B. Diasio Anne T. Nies Matthias Schwab Guido Cavaletti Eberhard Schlatter Giuliano Ciarimboli Jan H. M. Schellens Ehud Y. Isacoff Andrej Sali Taosheng Chen Sharyn D. Baker Alex Sparreboom Navjotsingh Pabla A phosphotyrosine switch regulates organic cation transporters |
| description |
Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug transporter function through post-translational mechanisms. |
| format |
article |
| author |
Jason A. Sprowl Su Sien Ong Alice A. Gibson Shuiying Hu Guoqing Du Wenwei Lin Lie Li Shashank Bharill Rachel A. Ness Adrian Stecula Steven M. Offer Robert B. Diasio Anne T. Nies Matthias Schwab Guido Cavaletti Eberhard Schlatter Giuliano Ciarimboli Jan H. M. Schellens Ehud Y. Isacoff Andrej Sali Taosheng Chen Sharyn D. Baker Alex Sparreboom Navjotsingh Pabla |
| author_facet |
Jason A. Sprowl Su Sien Ong Alice A. Gibson Shuiying Hu Guoqing Du Wenwei Lin Lie Li Shashank Bharill Rachel A. Ness Adrian Stecula Steven M. Offer Robert B. Diasio Anne T. Nies Matthias Schwab Guido Cavaletti Eberhard Schlatter Giuliano Ciarimboli Jan H. M. Schellens Ehud Y. Isacoff Andrej Sali Taosheng Chen Sharyn D. Baker Alex Sparreboom Navjotsingh Pabla |
| author_sort |
Jason A. Sprowl |
| title |
A phosphotyrosine switch regulates organic cation transporters |
| title_short |
A phosphotyrosine switch regulates organic cation transporters |
| title_full |
A phosphotyrosine switch regulates organic cation transporters |
| title_fullStr |
A phosphotyrosine switch regulates organic cation transporters |
| title_full_unstemmed |
A phosphotyrosine switch regulates organic cation transporters |
| title_sort |
phosphotyrosine switch regulates organic cation transporters |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/e23f1634f35944d0a0ca31c8bfbcf90b |
| work_keys_str_mv |
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