Structural insights into the function of ZRANB3 in replication stress response

ZRANB3 (Zinc-finger, RAN-Binding domain containing 3) is a structure-specific endonuclease that is recruited to DNA breaks and stressed replication forks. Here the authors present the crystal structure of the ZRANB3 endonuclease domain and analyse how ZRANB3 is regulated by the DNA clamp PCNA.

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Autores principales: Marek Sebesta, Christopher D. O. Cooper, Antonio Ariza, Christopher J. Carnie, Dragana Ahel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/e255a9bc2f6248c5a18735606cd0c8fe
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