Structural insights into the function of ZRANB3 in replication stress response

ZRANB3 (Zinc-finger, RAN-Binding domain containing 3) is a structure-specific endonuclease that is recruited to DNA breaks and stressed replication forks. Here the authors present the crystal structure of the ZRANB3 endonuclease domain and analyse how ZRANB3 is regulated by the DNA clamp PCNA.

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Autores principales:	Marek Sebesta, Christopher D. O. Cooper, Antonio Ariza, Christopher J. Carnie, Dragana Ahel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e255a9bc2f6248c5a18735606cd0c8fe
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spelling	oai:doaj.org-article:e255a9bc2f6248c5a18735606cd0c8fe2021-12-02T15:36:59ZStructural insights into the function of ZRANB3 in replication stress response10.1038/ncomms158472041-1723https://doaj.org/article/e255a9bc2f6248c5a18735606cd0c8fe2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15847https://doaj.org/toc/2041-1723ZRANB3 (Zinc-finger, RAN-Binding domain containing 3) is a structure-specific endonuclease that is recruited to DNA breaks and stressed replication forks. Here the authors present the crystal structure of the ZRANB3 endonuclease domain and analyse how ZRANB3 is regulated by the DNA clamp PCNA.Marek SebestaChristopher D. O. CooperAntonio ArizaChristopher J. CarnieDragana AhelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marek Sebesta Christopher D. O. Cooper Antonio Ariza Christopher J. Carnie Dragana Ahel Structural insights into the function of ZRANB3 in replication stress response
description	ZRANB3 (Zinc-finger, RAN-Binding domain containing 3) is a structure-specific endonuclease that is recruited to DNA breaks and stressed replication forks. Here the authors present the crystal structure of the ZRANB3 endonuclease domain and analyse how ZRANB3 is regulated by the DNA clamp PCNA.
format	article
author	Marek Sebesta Christopher D. O. Cooper Antonio Ariza Christopher J. Carnie Dragana Ahel
author_facet	Marek Sebesta Christopher D. O. Cooper Antonio Ariza Christopher J. Carnie Dragana Ahel
author_sort	Marek Sebesta
title	Structural insights into the function of ZRANB3 in replication stress response
title_short	Structural insights into the function of ZRANB3 in replication stress response
title_full	Structural insights into the function of ZRANB3 in replication stress response
title_fullStr	Structural insights into the function of ZRANB3 in replication stress response
title_full_unstemmed	Structural insights into the function of ZRANB3 in replication stress response
title_sort	structural insights into the function of zranb3 in replication stress response
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e255a9bc2f6248c5a18735606cd0c8fe
work_keys_str_mv	AT mareksebesta structuralinsightsintothefunctionofzranb3inreplicationstressresponse AT christopherdocooper structuralinsightsintothefunctionofzranb3inreplicationstressresponse AT antonioariza structuralinsightsintothefunctionofzranb3inreplicationstressresponse AT christopherjcarnie structuralinsightsintothefunctionofzranb3inreplicationstressresponse AT draganaahel structuralinsightsintothefunctionofzranb3inreplicationstressresponse
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Structural insights into the function of ZRANB3 in replication stress response

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