Diverging targets mediate the pathological roleof miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis

Diverging targets mediate the pathological roleof miR-199a-5p and miR-199a-3p by promoting cardiac hypertrophy and fibrosis

MicroRNA-199a-5p (miR-199a-5p) and -3p are enriched in the myocardium, but it is unknown whether miR-199a-5p and -3p are co-expressed in cardiac remodeling and what roles they have in cardiac hypertrophy and fibrosis. We show that miR-199a-5p and -3p are co-upregulated in the mouse and human myocard...

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Autores principales: Ni Zeng, Yu-Qing Huang, Yu-Min Yan, Zhi-Qin Hu, Zhuo Zhang, Jia-Xin Feng, Ji-Shen Guo, Jie-Ning Zhu, Yong-Heng Fu, Xi-Pei Wang, Meng-Zhen Zhang, Jin-Zhu Duan, Xi-Long Zheng, Jin-Dong Xu, Zhi-Xin Shan
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
microRNA
cardiac hypertrophy
cardiac fibrosis
microRNA-199a-5p
microRNA-199a-3p
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/e264f9859a5f4bd783e488783367e2ec
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https://doaj.org/article/e264f9859a5f4bd783e488783367e2ec

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