A distinct holoenzyme organization for two-subunit pyruvate carboxylase

Pyruvate carboxylases are homotetrameric enzymes in eukaryotes and most bacteria. Here, the authors report the structure of an unusual two-subunit form of the enzyme from the Gram-negative bacterium Methylobacillus flagellates, revealing an unexpected α2β4stoichiometry.

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Autores principales:	Philip H. Choi, Jeanyoung Jo, Yu-Cheng Lin, Min-Han Lin, Chi-Yuan Chou, Lars E. P. Dietrich, Liang Tong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e289b0f367274707a7bceab080bc093b
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id	oai:doaj.org-article:e289b0f367274707a7bceab080bc093b
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spelling	oai:doaj.org-article:e289b0f367274707a7bceab080bc093b2021-12-02T16:49:24ZA distinct holoenzyme organization for two-subunit pyruvate carboxylase10.1038/ncomms127132041-1723https://doaj.org/article/e289b0f367274707a7bceab080bc093b2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12713https://doaj.org/toc/2041-1723Pyruvate carboxylases are homotetrameric enzymes in eukaryotes and most bacteria. Here, the authors report the structure of an unusual two-subunit form of the enzyme from the Gram-negative bacterium Methylobacillus flagellates, revealing an unexpected α2β4stoichiometry.Philip H. ChoiJeanyoung JoYu-Cheng LinMin-Han LinChi-Yuan ChouLars E. P. DietrichLiang TongNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philip H. Choi Jeanyoung Jo Yu-Cheng Lin Min-Han Lin Chi-Yuan Chou Lars E. P. Dietrich Liang Tong A distinct holoenzyme organization for two-subunit pyruvate carboxylase
description	Pyruvate carboxylases are homotetrameric enzymes in eukaryotes and most bacteria. Here, the authors report the structure of an unusual two-subunit form of the enzyme from the Gram-negative bacterium Methylobacillus flagellates, revealing an unexpected α2β4stoichiometry.
format	article
author	Philip H. Choi Jeanyoung Jo Yu-Cheng Lin Min-Han Lin Chi-Yuan Chou Lars E. P. Dietrich Liang Tong
author_facet	Philip H. Choi Jeanyoung Jo Yu-Cheng Lin Min-Han Lin Chi-Yuan Chou Lars E. P. Dietrich Liang Tong
author_sort	Philip H. Choi
title	A distinct holoenzyme organization for two-subunit pyruvate carboxylase
title_short	A distinct holoenzyme organization for two-subunit pyruvate carboxylase
title_full	A distinct holoenzyme organization for two-subunit pyruvate carboxylase
title_fullStr	A distinct holoenzyme organization for two-subunit pyruvate carboxylase
title_full_unstemmed	A distinct holoenzyme organization for two-subunit pyruvate carboxylase
title_sort	distinct holoenzyme organization for two-subunit pyruvate carboxylase
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e289b0f367274707a7bceab080bc093b
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A distinct holoenzyme organization for two-subunit pyruvate carboxylase

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