Dimethyl Fumarate Ameliorates Nucleus Pulposus Cell Dysfunction through Activating the Nrf2/HO-1 Pathway in Intervertebral Disc Degeneration
Background. Oxidative stress, inflammation, and nucleus pulposus cells (NPCs) apoptosis are involved in pathogenesis of intervertebral disc (IVD) degeneration (IVDD). Dimethyl fumarate (DMF) has been found to effectively depress oxidative stress and inflammation via the Nrf2 pathway. Hence, this pro...
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| Main Authors: | , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Hindawi Limited
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/e28a3a5b108942fdb65b322dcb56380f |
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