Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung

Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung

Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating  these collagen III/CD167a-driven metastatic foci.

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Detalles Bibliográficos
Autores principales: Yu-Cheng Lee, Antonina V. Kurtova, Jing Xiao, Fotis Nikolos, Kazukuni Hayashi, Zoe Tramel, Antrix Jain, Fengju Chen, Mithil Chokshi, Ciaran Lee, Gang Bao, Xiang Zhang, Jianjun Shen, Qianxing Mo, Sung Yun Jung, David Rowley, Keith Syson Chan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/e28efd010f77438cb52345033d6f9096
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https://doaj.org/article/e28efd010f77438cb52345033d6f9096

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