Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung

Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating these collagen III/CD167a-driven metastatic foci.

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Autores principales:	Yu-Cheng Lee, Antonina V. Kurtova, Jing Xiao, Fotis Nikolos, Kazukuni Hayashi, Zoe Tramel, Antrix Jain, Fengju Chen, Mithil Chokshi, Ciaran Lee, Gang Bao, Xiang Zhang, Jianjun Shen, Qianxing Mo, Sung Yun Jung, David Rowley, Keith Syson Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e28efd010f77438cb52345033d6f9096
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spelling	oai:doaj.org-article:e28efd010f77438cb52345033d6f90962021-12-02T17:02:01ZCollagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung10.1038/s41467-019-09878-42041-1723https://doaj.org/article/e28efd010f77438cb52345033d6f90962019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09878-4https://doaj.org/toc/2041-1723Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating these collagen III/CD167a-driven metastatic foci.Yu-Cheng LeeAntonina V. KurtovaJing XiaoFotis NikolosKazukuni HayashiZoe TramelAntrix JainFengju ChenMithil ChokshiCiaran LeeGang BaoXiang ZhangJianjun ShenQianxing MoSung Yun JungDavid RowleyKeith Syson ChanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Cheng Lee Antonina V. Kurtova Jing Xiao Fotis Nikolos Kazukuni Hayashi Zoe Tramel Antrix Jain Fengju Chen Mithil Chokshi Ciaran Lee Gang Bao Xiang Zhang Jianjun Shen Qianxing Mo Sung Yun Jung David Rowley Keith Syson Chan Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
description	Collagen is a dynamic component of both the tumor and metastatic niche. Here, the authors show that airway smooth muscle cells are a collagen III rich niche bladder cancer cells expressing CD167a, and Stat3 is a downstream target for abrogating these collagen III/CD167a-driven metastatic foci.
format	article
author	Yu-Cheng Lee Antonina V. Kurtova Jing Xiao Fotis Nikolos Kazukuni Hayashi Zoe Tramel Antrix Jain Fengju Chen Mithil Chokshi Ciaran Lee Gang Bao Xiang Zhang Jianjun Shen Qianxing Mo Sung Yun Jung David Rowley Keith Syson Chan
author_facet	Yu-Cheng Lee Antonina V. Kurtova Jing Xiao Fotis Nikolos Kazukuni Hayashi Zoe Tramel Antrix Jain Fengju Chen Mithil Chokshi Ciaran Lee Gang Bao Xiang Zhang Jianjun Shen Qianxing Mo Sung Yun Jung David Rowley Keith Syson Chan
author_sort	Yu-Cheng Lee
title	Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
title_short	Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
title_full	Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
title_fullStr	Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
title_full_unstemmed	Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
title_sort	collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e28efd010f77438cb52345033d6f9096
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Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung

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