Construction and validation of a regulatory network for pluripotency and self-renewal of mouse embryonic stem cells.

A 30-node signed and directed network responsible for self-renewal and pluripotency of mouse embryonic stem cells (mESCs) was extracted from several ChIP-Seq and knockdown followed by expression prior studies. The underlying regulatory logic among network components was then learned using the initia...

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Autores principales: Huilei Xu, Yen-Sin Ang, Ana Sevilla, Ihor R Lemischka, Avi Ma'ayan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/e28f242edeaf49a8b2254fc2ceefa4b2
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