STAT1 signaling shields T cells from NK cell-mediated cytotoxicity
The JAK-STAT signaling pathway is important for cytokine responses and CD4 T-cell differentiation. Here the authors show that Stat1 also serves to protect CD4 T cells from natural killer cell-mediated killing, potentially by promoting the expression of Nlrc5 and MHC-I, to preserve the induction of e...
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Nature Portfolio
2019
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oai:doaj.org-article:e2c19505251948a095d635858a39e1962021-12-02T16:57:24ZSTAT1 signaling shields T cells from NK cell-mediated cytotoxicity10.1038/s41467-019-08743-82041-1723https://doaj.org/article/e2c19505251948a095d635858a39e1962019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08743-8https://doaj.org/toc/2041-1723The JAK-STAT signaling pathway is important for cytokine responses and CD4 T-cell differentiation. Here the authors show that Stat1 also serves to protect CD4 T cells from natural killer cell-mediated killing, potentially by promoting the expression of Nlrc5 and MHC-I, to preserve the induction of experimental colitis via the adoptive transfer of CD4 T cells.Yu Hui KangAmlan BiswasMichael FieldScott B. SnapperNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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Science Q Yu Hui Kang Amlan Biswas Michael Field Scott B. Snapper STAT1 signaling shields T cells from NK cell-mediated cytotoxicity |
description |
The JAK-STAT signaling pathway is important for cytokine responses and CD4 T-cell differentiation. Here the authors show that Stat1 also serves to protect CD4 T cells from natural killer cell-mediated killing, potentially by promoting the expression of Nlrc5 and MHC-I, to preserve the induction of experimental colitis via the adoptive transfer of CD4 T cells. |
format |
article |
author |
Yu Hui Kang Amlan Biswas Michael Field Scott B. Snapper |
author_facet |
Yu Hui Kang Amlan Biswas Michael Field Scott B. Snapper |
author_sort |
Yu Hui Kang |
title |
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity |
title_short |
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity |
title_full |
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity |
title_fullStr |
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity |
title_full_unstemmed |
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity |
title_sort |
stat1 signaling shields t cells from nk cell-mediated cytotoxicity |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/e2c19505251948a095d635858a39e196 |
work_keys_str_mv |
AT yuhuikang stat1signalingshieldstcellsfromnkcellmediatedcytotoxicity AT amlanbiswas stat1signalingshieldstcellsfromnkcellmediatedcytotoxicity AT michaelfield stat1signalingshieldstcellsfromnkcellmediatedcytotoxicity AT scottbsnapper stat1signalingshieldstcellsfromnkcellmediatedcytotoxicity |
_version_ |
1718382595658481664 |