STAT1 signaling shields T cells from NK cell-mediated cytotoxicity

The JAK-STAT signaling pathway is important for cytokine responses and CD4 T-cell differentiation. Here the authors show that Stat1 also serves to protect CD4 T cells from natural killer cell-mediated killing, potentially by promoting the expression of Nlrc5 and MHC-I, to preserve the induction of e...

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Autores principales: Yu Hui Kang, Amlan Biswas, Michael Field, Scott B. Snapper
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/e2c19505251948a095d635858a39e196
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spelling oai:doaj.org-article:e2c19505251948a095d635858a39e1962021-12-02T16:57:24ZSTAT1 signaling shields T cells from NK cell-mediated cytotoxicity10.1038/s41467-019-08743-82041-1723https://doaj.org/article/e2c19505251948a095d635858a39e1962019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08743-8https://doaj.org/toc/2041-1723The JAK-STAT signaling pathway is important for cytokine responses and CD4 T-cell differentiation. Here the authors show that Stat1 also serves to protect CD4 T cells from natural killer cell-mediated killing, potentially by promoting the expression of Nlrc5 and MHC-I, to preserve the induction of experimental colitis via the adoptive transfer of CD4 T cells.Yu Hui KangAmlan BiswasMichael FieldScott B. SnapperNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu Hui Kang
Amlan Biswas
Michael Field
Scott B. Snapper
STAT1 signaling shields T cells from NK cell-mediated cytotoxicity
description The JAK-STAT signaling pathway is important for cytokine responses and CD4 T-cell differentiation. Here the authors show that Stat1 also serves to protect CD4 T cells from natural killer cell-mediated killing, potentially by promoting the expression of Nlrc5 and MHC-I, to preserve the induction of experimental colitis via the adoptive transfer of CD4 T cells.
format article
author Yu Hui Kang
Amlan Biswas
Michael Field
Scott B. Snapper
author_facet Yu Hui Kang
Amlan Biswas
Michael Field
Scott B. Snapper
author_sort Yu Hui Kang
title STAT1 signaling shields T cells from NK cell-mediated cytotoxicity
title_short STAT1 signaling shields T cells from NK cell-mediated cytotoxicity
title_full STAT1 signaling shields T cells from NK cell-mediated cytotoxicity
title_fullStr STAT1 signaling shields T cells from NK cell-mediated cytotoxicity
title_full_unstemmed STAT1 signaling shields T cells from NK cell-mediated cytotoxicity
title_sort stat1 signaling shields t cells from nk cell-mediated cytotoxicity
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/e2c19505251948a095d635858a39e196
work_keys_str_mv AT yuhuikang stat1signalingshieldstcellsfromnkcellmediatedcytotoxicity
AT amlanbiswas stat1signalingshieldstcellsfromnkcellmediatedcytotoxicity
AT michaelfield stat1signalingshieldstcellsfromnkcellmediatedcytotoxicity
AT scottbsnapper stat1signalingshieldstcellsfromnkcellmediatedcytotoxicity
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