Redox status of cysteines does not alter functional properties of human dUTPase but the Y54C mutation involved in monogenic diabetes decreases protein stability

Abstract Recently it was proposed that the redox status of cysteines acts as a redox switch to regulate both the oligomeric status and the activity of human dUTPase. In a separate report, a human dUTPase point mutation, resulting in a tyrosine to cysteine substitution (Y54C) was identified as the mo...

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Autores principales: Judit Eszter Szabó, Kinga Nyíri, Dániel Andrási, Judit Matejka, Olivér Ozahonics, Beáta Vértessy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e2ca105caedc490383b7eed748bef8b8
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