Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling

The cytokine interleukin 1α (IL-1α) plays an important role in inflammatory processes. Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1α, present the structure of the IL-1α/aptamer complex and show that this aptamer inhibits the IL-1α signaling pathway....

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Autores principales: Xiaoming Ren, Amy D. Gelinas, Ira von Carlowitz, Nebojsa Janjic, Anna Marie Pyle
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e2cdd527a9be48b8adaaa6d5896332bd
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