Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling

The cytokine interleukin 1α (IL-1α) plays an important role in inflammatory processes. Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1α, present the structure of the IL-1α/aptamer complex and show that this aptamer inhibits the IL-1α signaling pathway....

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Autores principales:	Xiaoming Ren, Amy D. Gelinas, Ira von Carlowitz, Nebojsa Janjic, Anna Marie Pyle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2cdd527a9be48b8adaaa6d5896332bd
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spelling	oai:doaj.org-article:e2cdd527a9be48b8adaaa6d5896332bd2021-12-02T14:42:00ZStructural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling10.1038/s41467-017-00864-22041-1723https://doaj.org/article/e2cdd527a9be48b8adaaa6d5896332bd2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00864-2https://doaj.org/toc/2041-1723The cytokine interleukin 1α (IL-1α) plays an important role in inflammatory processes. Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1α, present the structure of the IL-1α/aptamer complex and show that this aptamer inhibits the IL-1α signaling pathway.Xiaoming RenAmy D. GelinasIra von CarlowitzNebojsa JanjicAnna Marie PyleNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoming Ren Amy D. Gelinas Ira von Carlowitz Nebojsa Janjic Anna Marie Pyle Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
description	The cytokine interleukin 1α (IL-1α) plays an important role in inflammatory processes. Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1α, present the structure of the IL-1α/aptamer complex and show that this aptamer inhibits the IL-1α signaling pathway.
format	article
author	Xiaoming Ren Amy D. Gelinas Ira von Carlowitz Nebojsa Janjic Anna Marie Pyle
author_facet	Xiaoming Ren Amy D. Gelinas Ira von Carlowitz Nebojsa Janjic Anna Marie Pyle
author_sort	Xiaoming Ren
title	Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
title_short	Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
title_full	Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
title_fullStr	Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
title_full_unstemmed	Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
title_sort	structural basis for il-1α recognition by a modified dna aptamer that specifically inhibits il-1α signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e2cdd527a9be48b8adaaa6d5896332bd
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Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling

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