Trimetazidine and exercise provide comparable improvements to high fat diet-induced muscle dysfunction through enhancement of mitochondrial quality control

Abstract Obesity induces skeletal muscle dysfunction. The pathogenesis of which appears to substantially involve mitochondrial dysfunction, arising from impaired quality control. Exercise is a major therapeutic strategy against muscle dysfunction. Trimetazidine, a partial inhibitor of lipid oxidatio...

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Autores principales: Wenliang Zhang, Baiyang You, Dake Qi, Ling Qiu, Jeffrey W. Ripley-Gonzalez, Fan Zheng, Siqian Fu, Cui Li, Yaoshan Dun, Suixin Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e2f80afdf365485b81712d3ac7fe2b10
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