Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo

Efficient intracellular delivery of proteins by a multifunctional chimaeric peptide in vitro and in vivo

Protein delivery with cell-penetrating peptides suffers from ineffective endosomal escape and low tolerance in serum, thereby limiting treatment success. Here the authors present an intracellular protein delivery system and demonstrate efficient delivery in vitro and therapeutic efficacy in a liver...

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Main Authors: Siyuan Yu, Han Yang, Tingdong Li, Haifeng Pan, Shuling Ren, Guoxing Luo, Jinlu Jiang, Linqi Yu, Binbing Chen, Yali Zhang, Shaojuan Wang, Rui Tian, Tianying Zhang, Shiyin Zhang, Yixin Chen, Quan Yuan, Shengxiang Ge, Jun Zhang, Ningshao Xia
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/e30762d64de74ddb83def6a74c94fb19
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https://doaj.org/article/e30762d64de74ddb83def6a74c94fb19

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