Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

Germline mutations in homologous recombination (HR) DNA repair genes are linked to breast and ovarian cancer. Here, the authors show that mutually exclusive bi-allelic inactivation of HR genes are present in other cancer types and associated with genomic features of HR deficiency, expanding the pote...

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Autores principales: Nadeem Riaz, Pedro Blecua, Raymond S. Lim, Ronglai Shen, Daniel S. Higginson, Nils Weinhold, Larry Norton, Britta Weigelt, Simon N. Powell, Jorge S. Reis-Filho
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/e31117fa0ba445099c2675a88b60cb9a
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