Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

Germline mutations in homologous recombination (HR) DNA repair genes are linked to breast and ovarian cancer. Here, the authors show that mutually exclusive bi-allelic inactivation of HR genes are present in other cancer types and associated with genomic features of HR deficiency, expanding the pote...

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Autores principales:	Nadeem Riaz, Pedro Blecua, Raymond S. Lim, Ronglai Shen, Daniel S. Higginson, Nils Weinhold, Larry Norton, Britta Weigelt, Simon N. Powell, Jorge S. Reis-Filho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e31117fa0ba445099c2675a88b60cb9a
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spelling	oai:doaj.org-article:e31117fa0ba445099c2675a88b60cb9a2021-12-02T15:38:36ZPan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes10.1038/s41467-017-00921-w2041-1723https://doaj.org/article/e31117fa0ba445099c2675a88b60cb9a2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00921-whttps://doaj.org/toc/2041-1723Germline mutations in homologous recombination (HR) DNA repair genes are linked to breast and ovarian cancer. Here, the authors show that mutually exclusive bi-allelic inactivation of HR genes are present in other cancer types and associated with genomic features of HR deficiency, expanding the potential use of HR-directed therapies.Nadeem RiazPedro BlecuaRaymond S. LimRonglai ShenDaniel S. HigginsonNils WeinholdLarry NortonBritta WeigeltSimon N. PowellJorge S. Reis-FilhoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadeem Riaz Pedro Blecua Raymond S. Lim Ronglai Shen Daniel S. Higginson Nils Weinhold Larry Norton Britta Weigelt Simon N. Powell Jorge S. Reis-Filho Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes
description	Germline mutations in homologous recombination (HR) DNA repair genes are linked to breast and ovarian cancer. Here, the authors show that mutually exclusive bi-allelic inactivation of HR genes are present in other cancer types and associated with genomic features of HR deficiency, expanding the potential use of HR-directed therapies.
format	article
author	Nadeem Riaz Pedro Blecua Raymond S. Lim Ronglai Shen Daniel S. Higginson Nils Weinhold Larry Norton Britta Weigelt Simon N. Powell Jorge S. Reis-Filho
author_facet	Nadeem Riaz Pedro Blecua Raymond S. Lim Ronglai Shen Daniel S. Higginson Nils Weinhold Larry Norton Britta Weigelt Simon N. Powell Jorge S. Reis-Filho
author_sort	Nadeem Riaz
title	Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes
title_short	Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes
title_full	Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes
title_fullStr	Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes
title_full_unstemmed	Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes
title_sort	pan-cancer analysis of bi-allelic alterations in homologous recombination dna repair genes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e31117fa0ba445099c2675a88b60cb9a
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Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes

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