Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies

Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies

Many SNPs associated with inflammatory bowel disease are located in non-coding genomic regions. Here, the authors perform CAGE-sequencing on descending colon biopsies of Crohn’s disease and ulcerative colitis patients to map transcription start sites and enhancer activity for analysis of regulatory...

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Main Authors: Mette Boyd, Malte Thodberg, Morana Vitezic, Jette Bornholdt, Kristoffer Vitting-Seerup, Yun Chen, Mehmet Coskun, Yuan Li, Bobby Zhao Sheng Lo, Pia Klausen, Pawel Jan Schweiger, Anders Gorm Pedersen, Nicolas Rapin, Kerstin Skovgaard, Katja Dahlgaard, Robin Andersson, Thilde Bagger Terkelsen, Berit Lilje, Jesper Thorvald Troelsen, Andreas Munk Petersen, Kim Bak Jensen, Ismail Gögenur, Peter Thielsen, Jakob Benedict Seidelin, Ole Haagen Nielsen, Jacob Tveiten Bjerrum, Albin Sandelin
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/e32e0b001f3f40cfa76d4515cf61a036
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Summary:Many SNPs associated with inflammatory bowel disease are located in non-coding genomic regions. Here, the authors perform CAGE-sequencing on descending colon biopsies of Crohn’s disease and ulcerative colitis patients to map transcription start sites and enhancer activity for analysis of regulatory regions.

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