A Translational Pharmacokinetic Rat Model of Cerebral Spinal Fluid and Plasma Concentrations of Cefepime

ABSTRACT This study sought to define the transit of cefepime between plasma and cerebral spinal fluid (CSF) in a rat model. Male Sprague-Dawley rats received cefepime intravenously. A total daily dose of 150 mg/kg of body weight/day was administered as a single injection every 24 h for 4 days. Plasm...

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Autores principales: Sean N. Avedissian, Gwendolyn Pais, Medha D. Joshi, Nathaniel J. Rhodes, Marc H. Scheetz
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
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Acceso en línea:https://doaj.org/article/e369e04b7fa54d42997725c197c9cb6e
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