GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.

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Autores principales: Lauren A. Callender, Johannes Schroth, Elizabeth C. Carroll, Conor Garrod-Ketchley, Lisa E. L. Romano, Eleanor Hendy, Audrey Kelly, Paul Lavender, Arne N. Akbar, J. Paul Chapple, Sian M. Henson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/e3707e322df34c44b2251936c03964a1
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https://doaj.org/article/e3707e322df34c44b2251936c03964a1

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