GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.

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Autores principales: Lauren A. Callender, Johannes Schroth, Elizabeth C. Carroll, Conor Garrod-Ketchley, Lisa E. L. Romano, Eleanor Hendy, Audrey Kelly, Paul Lavender, Arne N. Akbar, J. Paul Chapple, Sian M. Henson
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e3707e322df34c44b2251936c03964a1
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spelling oai:doaj.org-article:e3707e322df34c44b2251936c03964a12021-12-02T17:52:09ZGATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage10.1038/s41467-021-23715-72041-1723https://doaj.org/article/e3707e322df34c44b2251936c03964a12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23715-7https://doaj.org/toc/2041-1723GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.Lauren A. CallenderJohannes SchrothElizabeth C. CarrollConor Garrod-KetchleyLisa E. L. RomanoEleanor HendyAudrey KellyPaul LavenderArne N. AkbarJ. Paul ChappleSian M. HensonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lauren A. Callender
Johannes Schroth
Elizabeth C. Carroll
Conor Garrod-Ketchley
Lisa E. L. Romano
Eleanor Hendy
Audrey Kelly
Paul Lavender
Arne N. Akbar
J. Paul Chapple
Sian M. Henson
GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
description GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.
format article
author Lauren A. Callender
Johannes Schroth
Elizabeth C. Carroll
Conor Garrod-Ketchley
Lisa E. L. Romano
Eleanor Hendy
Audrey Kelly
Paul Lavender
Arne N. Akbar
J. Paul Chapple
Sian M. Henson
author_facet Lauren A. Callender
Johannes Schroth
Elizabeth C. Carroll
Conor Garrod-Ketchley
Lisa E. L. Romano
Eleanor Hendy
Audrey Kelly
Paul Lavender
Arne N. Akbar
J. Paul Chapple
Sian M. Henson
author_sort Lauren A. Callender
title GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_short GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_full GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_fullStr GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_full_unstemmed GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_sort gata3 induces mitochondrial biogenesis in primary human cd4+ t cells during dna damage
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e3707e322df34c44b2251936c03964a1
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