GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.

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Auteurs principaux:	Lauren A. Callender, Johannes Schroth, Elizabeth C. Carroll, Conor Garrod-Ketchley, Lisa E. L. Romano, Eleanor Hendy, Audrey Kelly, Paul Lavender, Arne N. Akbar, J. Paul Chapple, Sian M. Henson
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e3707e322df34c44b2251936c03964a1
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spelling	oai:doaj.org-article:e3707e322df34c44b2251936c03964a12021-12-02T17:52:09ZGATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage10.1038/s41467-021-23715-72041-1723https://doaj.org/article/e3707e322df34c44b2251936c03964a12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23715-7https://doaj.org/toc/2041-1723GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.Lauren A. CallenderJohannes SchrothElizabeth C. CarrollConor Garrod-KetchleyLisa E. L. RomanoEleanor HendyAudrey KellyPaul LavenderArne N. AkbarJ. Paul ChappleSian M. HensonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lauren A. Callender Johannes Schroth Elizabeth C. Carroll Conor Garrod-Ketchley Lisa E. L. Romano Eleanor Hendy Audrey Kelly Paul Lavender Arne N. Akbar J. Paul Chapple Sian M. Henson GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
description	GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.
format	article
author	Lauren A. Callender Johannes Schroth Elizabeth C. Carroll Conor Garrod-Ketchley Lisa E. L. Romano Eleanor Hendy Audrey Kelly Paul Lavender Arne N. Akbar J. Paul Chapple Sian M. Henson
author_facet	Lauren A. Callender Johannes Schroth Elizabeth C. Carroll Conor Garrod-Ketchley Lisa E. L. Romano Eleanor Hendy Audrey Kelly Paul Lavender Arne N. Akbar J. Paul Chapple Sian M. Henson
author_sort	Lauren A. Callender
title	GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_short	GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_full	GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_fullStr	GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_full_unstemmed	GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
title_sort	gata3 induces mitochondrial biogenesis in primary human cd4+ t cells during dna damage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e3707e322df34c44b2251936c03964a1
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GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage

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