GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage
GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.
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Nature Portfolio
2021
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Acceso en línea: | https://doaj.org/article/e3707e322df34c44b2251936c03964a1 |
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oai:doaj.org-article:e3707e322df34c44b2251936c03964a12021-12-02T17:52:09ZGATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage10.1038/s41467-021-23715-72041-1723https://doaj.org/article/e3707e322df34c44b2251936c03964a12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23715-7https://doaj.org/toc/2041-1723GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK.Lauren A. CallenderJohannes SchrothElizabeth C. CarrollConor Garrod-KetchleyLisa E. L. RomanoEleanor HendyAudrey KellyPaul LavenderArne N. AkbarJ. Paul ChappleSian M. HensonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
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Science Q Lauren A. Callender Johannes Schroth Elizabeth C. Carroll Conor Garrod-Ketchley Lisa E. L. Romano Eleanor Hendy Audrey Kelly Paul Lavender Arne N. Akbar J. Paul Chapple Sian M. Henson GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage |
description |
GATA3 has been considered to be primarily associated with CD4+ Th2 cell function. Using CD4+ effector memory that re-express CD45RA (EMRA) T cells the authors show that in response to DNA damage GATA3 can regulate increase of mitochondrial mass and biogenesis involving AMPK. |
format |
article |
author |
Lauren A. Callender Johannes Schroth Elizabeth C. Carroll Conor Garrod-Ketchley Lisa E. L. Romano Eleanor Hendy Audrey Kelly Paul Lavender Arne N. Akbar J. Paul Chapple Sian M. Henson |
author_facet |
Lauren A. Callender Johannes Schroth Elizabeth C. Carroll Conor Garrod-Ketchley Lisa E. L. Romano Eleanor Hendy Audrey Kelly Paul Lavender Arne N. Akbar J. Paul Chapple Sian M. Henson |
author_sort |
Lauren A. Callender |
title |
GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage |
title_short |
GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage |
title_full |
GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage |
title_fullStr |
GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage |
title_full_unstemmed |
GATA3 induces mitochondrial biogenesis in primary human CD4+ T cells during DNA damage |
title_sort |
gata3 induces mitochondrial biogenesis in primary human cd4+ t cells during dna damage |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/e3707e322df34c44b2251936c03964a1 |
work_keys_str_mv |
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