Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process

Alpha-functionalized organic acids are building blocks of many bioactive compounds. Here, the authors developed a toolbox-like, modular set of enzymes that reset chiral groups, turning achiral glycine and simple aldehydes into stereodefined α-keto acids, α-hydroxy acids, and α-amino acids.

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Autores principales:	Wei Song, Jin-Hui Wang, Jing Wu, Jia Liu, Xiu-Lai Chen, Li-Ming Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e395fb7be3ba460d9ae480a09a69c7a8
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spelling	oai:doaj.org-article:e395fb7be3ba460d9ae480a09a69c7a82021-12-02T15:33:34ZAsymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process10.1038/s41467-018-06241-x2041-1723https://doaj.org/article/e395fb7be3ba460d9ae480a09a69c7a82018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06241-xhttps://doaj.org/toc/2041-1723Alpha-functionalized organic acids are building blocks of many bioactive compounds. Here, the authors developed a toolbox-like, modular set of enzymes that reset chiral groups, turning achiral glycine and simple aldehydes into stereodefined α-keto acids, α-hydroxy acids, and α-amino acids.Wei SongJin-Hui WangJing WuJia LiuXiu-Lai ChenLi-Ming LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Song Jin-Hui Wang Jing Wu Jia Liu Xiu-Lai Chen Li-Ming Liu Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process
description	Alpha-functionalized organic acids are building blocks of many bioactive compounds. Here, the authors developed a toolbox-like, modular set of enzymes that reset chiral groups, turning achiral glycine and simple aldehydes into stereodefined α-keto acids, α-hydroxy acids, and α-amino acids.
format	article
author	Wei Song Jin-Hui Wang Jing Wu Jia Liu Xiu-Lai Chen Li-Ming Liu
author_facet	Wei Song Jin-Hui Wang Jing Wu Jia Liu Xiu-Lai Chen Li-Ming Liu
author_sort	Wei Song
title	Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process
title_short	Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process
title_full	Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process
title_fullStr	Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process
title_full_unstemmed	Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process
title_sort	asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e395fb7be3ba460d9ae480a09a69c7a8
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Asymmetric assembly of high-value α-functionalized organic acids using a biocatalytic chiral-group-resetting process

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