Olanzapine induced reproductive toxicity in male rats

Abstract Although it is reported that olanzapine (OLZ), which is an atypical antipsychotic drug, causes sexual dysfunction in men, it is noteworthy that there is not any study evaluating the toxic effects of OLZ on the male reproductive system. In the scope of this research, it was aimed to assess t...

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Autores principales:	Cankız Mina Ardıç, Sinem Ilgın, Merve Baysal, A. Burak Karaduman, Volkan Kılıç, Gözde Aydoğan-Kılıç, Şeyda Uçarcan, Özlem Atlı-Eklioğlu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e39f4272ea974f21a5a597316552945d
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spelling	oai:doaj.org-article:e39f4272ea974f21a5a597316552945d2021-12-02T13:20:04ZOlanzapine induced reproductive toxicity in male rats10.1038/s41598-021-84235-42045-2322https://doaj.org/article/e39f4272ea974f21a5a597316552945d2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84235-4https://doaj.org/toc/2045-2322Abstract Although it is reported that olanzapine (OLZ), which is an atypical antipsychotic drug, causes sexual dysfunction in men, it is noteworthy that there is not any study evaluating the toxic effects of OLZ on the male reproductive system. In the scope of this research, it was aimed to assess the reproductive toxic effects of OLZ by oral administration of 2.5, 5, or 10 mg/kg of it to male rats for 28 days. For this purpose, sperm concentration, motility and morphology, and DNA damage were determined, and histopathological examination of testis tissue was carried out in rats. Also, the levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone, which play roles in the regulation of reproductive functions, and the levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA) which play roles in reproductive pathologies as oxidative stress biomarkers, were determined. According to the results, normal sperm morphology was decreased in 5 ve 10 mg/kg OLZ-administered groups, and pathological findings were evident in the testicular structure of the OLZ-administered group when compared with the control group. It was determined that serum LH, FSH, and testosterone levels were decreased in the OLZ-administered group. Also, decreases of GSH levels in testis tissue were determined and evaluated as the markers of the oxidative stress induced by OLZ in the testis. In conclusion, it was determined that reproductive toxic effects were induced in rats by OLZ administration. This pathology was accompanied by alterations of the hormone levels and testicular oxidative stress.Cankız Mina ArdıçSinem IlgınMerve BaysalA. Burak KaradumanVolkan KılıçGözde Aydoğan-KılıçŞeyda UçarcanÖzlem Atlı-EklioğluNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cankız Mina Ardıç Sinem Ilgın Merve Baysal A. Burak Karaduman Volkan Kılıç Gözde Aydoğan-Kılıç Şeyda Uçarcan Özlem Atlı-Eklioğlu Olanzapine induced reproductive toxicity in male rats
description	Abstract Although it is reported that olanzapine (OLZ), which is an atypical antipsychotic drug, causes sexual dysfunction in men, it is noteworthy that there is not any study evaluating the toxic effects of OLZ on the male reproductive system. In the scope of this research, it was aimed to assess the reproductive toxic effects of OLZ by oral administration of 2.5, 5, or 10 mg/kg of it to male rats for 28 days. For this purpose, sperm concentration, motility and morphology, and DNA damage were determined, and histopathological examination of testis tissue was carried out in rats. Also, the levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone, which play roles in the regulation of reproductive functions, and the levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and malondialdehyde (MDA) which play roles in reproductive pathologies as oxidative stress biomarkers, were determined. According to the results, normal sperm morphology was decreased in 5 ve 10 mg/kg OLZ-administered groups, and pathological findings were evident in the testicular structure of the OLZ-administered group when compared with the control group. It was determined that serum LH, FSH, and testosterone levels were decreased in the OLZ-administered group. Also, decreases of GSH levels in testis tissue were determined and evaluated as the markers of the oxidative stress induced by OLZ in the testis. In conclusion, it was determined that reproductive toxic effects were induced in rats by OLZ administration. This pathology was accompanied by alterations of the hormone levels and testicular oxidative stress.
format	article
author	Cankız Mina Ardıç Sinem Ilgın Merve Baysal A. Burak Karaduman Volkan Kılıç Gözde Aydoğan-Kılıç Şeyda Uçarcan Özlem Atlı-Eklioğlu
author_facet	Cankız Mina Ardıç Sinem Ilgın Merve Baysal A. Burak Karaduman Volkan Kılıç Gözde Aydoğan-Kılıç Şeyda Uçarcan Özlem Atlı-Eklioğlu
author_sort	Cankız Mina Ardıç
title	Olanzapine induced reproductive toxicity in male rats
title_short	Olanzapine induced reproductive toxicity in male rats
title_full	Olanzapine induced reproductive toxicity in male rats
title_fullStr	Olanzapine induced reproductive toxicity in male rats
title_full_unstemmed	Olanzapine induced reproductive toxicity in male rats
title_sort	olanzapine induced reproductive toxicity in male rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e39f4272ea974f21a5a597316552945d
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Olanzapine induced reproductive toxicity in male rats

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