Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats.
<h4>Background</h4>In this study, the neuroprotective effect of a novel nonpeptide AT2R agonist, C21, was examined in a conscious model of stroke to verify a class effect of AT2R agonists as neuroprotective agents.<h4>Methods and results</h4>Spontaneously hypertensive rats (S...
Guardado en:
Autores principales: | Claudia A McCarthy, Antony Vinh, Alyson A Miller, Anders Hallberg, Mathias Alterman, Jennifer K Callaway, Robert E Widdop |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
|
Materias: | |
Acceso en línea: | https://doaj.org/article/e3e2ac36c92a4fceb1b89559b68dc59f |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury
por: Menk M, et al.
Publicado: (2018) -
Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma
por: Michal Geva, et al.
Publicado: (2021) -
Angiotensin II promotes the anticoagulant effects of rivaroxaban via angiotensin type 2 receptor signaling in mice
por: Dan Yang, et al.
Publicado: (2017) -
TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity
por: Xiaojie Yu, et al.
Publicado: (2021) -
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation
por: Chuan Hong, et al.
Publicado: (2021)