Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis
Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and inflammation induce the development of colonic tumours w...
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Nature Portfolio
2021
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oai:doaj.org-article:e406c430dd004d04b04b4ed7f56f1c672021-12-02T18:06:34ZOncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis10.1038/s41467-021-23717-52041-1723https://doaj.org/article/e406c430dd004d04b04b4ed7f56f1c672021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23717-5https://doaj.org/toc/2041-1723Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and inflammation induce the development of colonic tumours with a foetal-like phenotype.Joshua D. G. LeachNikola VlahovPetros TsantoulisRachel A. RidgwayDustin J. FlanaganKathryn GilroyNathalie SphyrisEster G. VázquezDavid F. VincentWilliam J. FallerMichael C. HodderAlexander RavenSigrid FeyArafath K. NajumudeenDouglas StrathdeeColin NixonMark HughesWilliam ClarkRobin ShawS:CORT consortiumSander R. van HooffDavid J. HuelsJan Paul MedemaSimon T. BarryMargaret C. FrameAsier Unciti-BrocetaSimon J. LeedhamGareth J. InmanRene JackstadtBarry J. ThompsonAndrew D. CampbellSabine TejparOwen J. SansomNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Joshua D. G. Leach Nikola Vlahov Petros Tsantoulis Rachel A. Ridgway Dustin J. Flanagan Kathryn Gilroy Nathalie Sphyris Ester G. Vázquez David F. Vincent William J. Faller Michael C. Hodder Alexander Raven Sigrid Fey Arafath K. Najumudeen Douglas Strathdee Colin Nixon Mark Hughes William Clark Robin Shaw S:CORT consortium Sander R. van Hooff David J. Huels Jan Paul Medema Simon T. Barry Margaret C. Frame Asier Unciti-Broceta Simon J. Leedham Gareth J. Inman Rene Jackstadt Barry J. Thompson Andrew D. Campbell Sabine Tejpar Owen J. Sansom Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis |
| description |
Right-sided colorectal cancer (rCRC) has a different mutational spectrum to the left-sided counterpart. Here the authors develop a mouse model of rCRC that recapitulates human BRAF-mutant rCRC and show that loss of TGFβ-receptor signalling and inflammation induce the development of colonic tumours with a foetal-like phenotype. |
| format |
article |
| author |
Joshua D. G. Leach Nikola Vlahov Petros Tsantoulis Rachel A. Ridgway Dustin J. Flanagan Kathryn Gilroy Nathalie Sphyris Ester G. Vázquez David F. Vincent William J. Faller Michael C. Hodder Alexander Raven Sigrid Fey Arafath K. Najumudeen Douglas Strathdee Colin Nixon Mark Hughes William Clark Robin Shaw S:CORT consortium Sander R. van Hooff David J. Huels Jan Paul Medema Simon T. Barry Margaret C. Frame Asier Unciti-Broceta Simon J. Leedham Gareth J. Inman Rene Jackstadt Barry J. Thompson Andrew D. Campbell Sabine Tejpar Owen J. Sansom |
| author_facet |
Joshua D. G. Leach Nikola Vlahov Petros Tsantoulis Rachel A. Ridgway Dustin J. Flanagan Kathryn Gilroy Nathalie Sphyris Ester G. Vázquez David F. Vincent William J. Faller Michael C. Hodder Alexander Raven Sigrid Fey Arafath K. Najumudeen Douglas Strathdee Colin Nixon Mark Hughes William Clark Robin Shaw S:CORT consortium Sander R. van Hooff David J. Huels Jan Paul Medema Simon T. Barry Margaret C. Frame Asier Unciti-Broceta Simon J. Leedham Gareth J. Inman Rene Jackstadt Barry J. Thompson Andrew D. Campbell Sabine Tejpar Owen J. Sansom |
| author_sort |
Joshua D. G. Leach |
| title |
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis |
| title_short |
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis |
| title_full |
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis |
| title_fullStr |
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis |
| title_full_unstemmed |
Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis |
| title_sort |
oncogenic braf, unrestrained by tgfβ-receptor signalling, drives right-sided colonic tumorigenesis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e406c430dd004d04b04b4ed7f56f1c67 |
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