Generic wound signals initiate regeneration in missing-tissue contexts

Some wounds trigger regeneration, while others simply heal but how this is regulated is unclear. Here, by manipulating ERK and Wnt signalling pathways, the authors create headless planarians and finless zebrafish and show that wounds that normally only trigger wound healing can activate regeneration...

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Autores principales:	Suthira Owlarn, Felix Klenner, David Schmidt, Franziska Rabert, Antonio Tomasso, Hanna Reuter, Medhanie A. Mulaw, Sören Moritz, Luca Gentile, Gilbert Weidinger, Kerstin Bartscherer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4121786dfd84d7e91076c345878d239
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spelling	oai:doaj.org-article:e4121786dfd84d7e91076c345878d2392021-12-02T14:42:35ZGeneric wound signals initiate regeneration in missing-tissue contexts10.1038/s41467-017-02338-x2041-1723https://doaj.org/article/e4121786dfd84d7e91076c345878d2392017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02338-xhttps://doaj.org/toc/2041-1723Some wounds trigger regeneration, while others simply heal but how this is regulated is unclear. Here, by manipulating ERK and Wnt signalling pathways, the authors create headless planarians and finless zebrafish and show that wounds that normally only trigger wound healing can activate regeneration of heads and bones.Suthira OwlarnFelix KlennerDavid SchmidtFranziska RabertAntonio TomassoHanna ReuterMedhanie A. MulawSören MoritzLuca GentileGilbert WeidingerKerstin BartschererNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Suthira Owlarn Felix Klenner David Schmidt Franziska Rabert Antonio Tomasso Hanna Reuter Medhanie A. Mulaw Sören Moritz Luca Gentile Gilbert Weidinger Kerstin Bartscherer Generic wound signals initiate regeneration in missing-tissue contexts
description	Some wounds trigger regeneration, while others simply heal but how this is regulated is unclear. Here, by manipulating ERK and Wnt signalling pathways, the authors create headless planarians and finless zebrafish and show that wounds that normally only trigger wound healing can activate regeneration of heads and bones.
format	article
author	Suthira Owlarn Felix Klenner David Schmidt Franziska Rabert Antonio Tomasso Hanna Reuter Medhanie A. Mulaw Sören Moritz Luca Gentile Gilbert Weidinger Kerstin Bartscherer
author_facet	Suthira Owlarn Felix Klenner David Schmidt Franziska Rabert Antonio Tomasso Hanna Reuter Medhanie A. Mulaw Sören Moritz Luca Gentile Gilbert Weidinger Kerstin Bartscherer
author_sort	Suthira Owlarn
title	Generic wound signals initiate regeneration in missing-tissue contexts
title_short	Generic wound signals initiate regeneration in missing-tissue contexts
title_full	Generic wound signals initiate regeneration in missing-tissue contexts
title_fullStr	Generic wound signals initiate regeneration in missing-tissue contexts
title_full_unstemmed	Generic wound signals initiate regeneration in missing-tissue contexts
title_sort	generic wound signals initiate regeneration in missing-tissue contexts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e4121786dfd84d7e91076c345878d239
work_keys_str_mv	AT suthiraowlarn genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT felixklenner genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT davidschmidt genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT franziskarabert genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT antoniotomasso genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT hannareuter genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT medhanieamulaw genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT sorenmoritz genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT lucagentile genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT gilbertweidinger genericwoundsignalsinitiateregenerationinmissingtissuecontexts AT kerstinbartscherer genericwoundsignalsinitiateregenerationinmissingtissuecontexts
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Generic wound signals initiate regeneration in missing-tissue contexts

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