TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains

The TGFβ signaling pathway has been shown to regulate transcription by regulating enhancer activity. Here, the authors perform a comprehensive analysis of enhancers in normal mammary epithelial gland cells to elucidate how TGFβ-dependent enhancers control gene transcription in these cells.

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Autores principales: Jose A. Guerrero-Martínez, María Ceballos-Chávez, Florian Koehler, Sandra Peiró, Jose C. Reyes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e45dcaf31ff0412eb73ec311a217cbda
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