TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains

The TGFβ signaling pathway has been shown to regulate transcription by regulating enhancer activity. Here, the authors perform a comprehensive analysis of enhancers in normal mammary epithelial gland cells to elucidate how TGFβ-dependent enhancers control gene transcription in these cells.

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Autores principales:	Jose A. Guerrero-Martínez, María Ceballos-Chávez, Florian Koehler, Sandra Peiró, Jose C. Reyes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e45dcaf31ff0412eb73ec311a217cbda
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spelling	oai:doaj.org-article:e45dcaf31ff0412eb73ec311a217cbda2021-12-02T17:31:07ZTGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains10.1038/s41467-020-19877-52041-1723https://doaj.org/article/e45dcaf31ff0412eb73ec311a217cbda2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19877-5https://doaj.org/toc/2041-1723The TGFβ signaling pathway has been shown to regulate transcription by regulating enhancer activity. Here, the authors perform a comprehensive analysis of enhancers in normal mammary epithelial gland cells to elucidate how TGFβ-dependent enhancers control gene transcription in these cells.Jose A. Guerrero-MartínezMaría Ceballos-ChávezFlorian KoehlerSandra PeiróJose C. ReyesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jose A. Guerrero-Martínez María Ceballos-Chávez Florian Koehler Sandra Peiró Jose C. Reyes TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
description	The TGFβ signaling pathway has been shown to regulate transcription by regulating enhancer activity. Here, the authors perform a comprehensive analysis of enhancers in normal mammary epithelial gland cells to elucidate how TGFβ-dependent enhancers control gene transcription in these cells.
format	article
author	Jose A. Guerrero-Martínez María Ceballos-Chávez Florian Koehler Sandra Peiró Jose C. Reyes
author_facet	Jose A. Guerrero-Martínez María Ceballos-Chávez Florian Koehler Sandra Peiró Jose C. Reyes
author_sort	Jose A. Guerrero-Martínez
title	TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
title_short	TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
title_full	TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
title_fullStr	TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
title_full_unstemmed	TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
title_sort	tgfβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e45dcaf31ff0412eb73ec311a217cbda
work_keys_str_mv	AT joseaguerreromartinez tgfbpromoteswidespreadenhancerchromatinopeningandoperatesongenomicregulatorydomains AT mariaceballoschavez tgfbpromoteswidespreadenhancerchromatinopeningandoperatesongenomicregulatorydomains AT floriankoehler tgfbpromoteswidespreadenhancerchromatinopeningandoperatesongenomicregulatorydomains AT sandrapeiro tgfbpromoteswidespreadenhancerchromatinopeningandoperatesongenomicregulatorydomains AT josecreyes tgfbpromoteswidespreadenhancerchromatinopeningandoperatesongenomicregulatorydomains
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TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains

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