Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the association of NUP98-PHD finger chimeras with H3K4me3-rich...

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Autores principales: Yi Zhang, Yiran Guo, Sheryl M. Gough, Jinyong Zhang, Kendra R. Vann, Kuai Li, Ling Cai, Xiaobing Shi, Peter D. Aplan, Gang Greg Wang, Tatiana G. Kutateladze
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e4bca98ea1b04bc8b103565804db9ae0
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