Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the association of NUP98-PHD finger chimeras with H3K4me3-rich...

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Autores principales:	Yi Zhang, Yiran Guo, Sheryl M. Gough, Jinyong Zhang, Kendra R. Vann, Kuai Li, Ling Cai, Xiaobing Shi, Peter D. Aplan, Gang Greg Wang, Tatiana G. Kutateladze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4bca98ea1b04bc8b103565804db9ae0
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spelling	oai:doaj.org-article:e4bca98ea1b04bc8b103565804db9ae02021-12-02T16:13:43ZMechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion10.1038/s41467-020-17098-42041-1723https://doaj.org/article/e4bca98ea1b04bc8b103565804db9ae02020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17098-4https://doaj.org/toc/2041-1723Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the association of NUP98-PHD finger chimeras with H3K4me3-rich regions and leukemic transformation.Yi ZhangYiran GuoSheryl M. GoughJinyong ZhangKendra R. VannKuai LiLing CaiXiaobing ShiPeter D. AplanGang Greg WangTatiana G. KutateladzeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Zhang Yiran Guo Sheryl M. Gough Jinyong Zhang Kendra R. Vann Kuai Li Ling Cai Xiaobing Shi Peter D. Aplan Gang Greg Wang Tatiana G. Kutateladze Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
description	Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the association of NUP98-PHD finger chimeras with H3K4me3-rich regions and leukemic transformation.
format	article
author	Yi Zhang Yiran Guo Sheryl M. Gough Jinyong Zhang Kendra R. Vann Kuai Li Ling Cai Xiaobing Shi Peter D. Aplan Gang Greg Wang Tatiana G. Kutateladze
author_facet	Yi Zhang Yiran Guo Sheryl M. Gough Jinyong Zhang Kendra R. Vann Kuai Li Ling Cai Xiaobing Shi Peter D. Aplan Gang Greg Wang Tatiana G. Kutateladze
author_sort	Yi Zhang
title	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_short	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_full	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_fullStr	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_full_unstemmed	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_sort	mechanistic insights into chromatin targeting by leukemic nup98-phf23 fusion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e4bca98ea1b04bc8b103565804db9ae0
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Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

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