Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Leukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of resistant leukaemia cells bothin vitro and in vivo.

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Autores principales:	Carlos Boto, Emanuel Quartin, Yijun Cai, Alberto Martín-Lorenzo, María Begoña García Cenador, Sandra Pinto, Rajeev Gupta, Tariq Enver, Isidro Sánchez-García, Dengli Hong, Ricardo Pires das Neves, Lino Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4bdd43ae19445c3acce605c66e63d91
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spelling	oai:doaj.org-article:e4bdd43ae19445c3acce605c66e63d912021-12-02T14:42:04ZProlonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation10.1038/ncomms152042041-1723https://doaj.org/article/e4bdd43ae19445c3acce605c66e63d912017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15204https://doaj.org/toc/2041-1723Leukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of resistant leukaemia cells bothin vitro and in vivo.Carlos BotoEmanuel QuartinYijun CaiAlberto Martín-LorenzoMaría Begoña García CenadorSandra PintoRajeev GuptaTariq EnverIsidro Sánchez-GarcíaDengli HongRicardo Pires das NevesLino FerreiraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carlos Boto Emanuel Quartin Yijun Cai Alberto Martín-Lorenzo María Begoña García Cenador Sandra Pinto Rajeev Gupta Tariq Enver Isidro Sánchez-García Dengli Hong Ricardo Pires das Neves Lino Ferreira Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
description	Leukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of resistant leukaemia cells bothin vitro and in vivo.
format	article
author	Carlos Boto Emanuel Quartin Yijun Cai Alberto Martín-Lorenzo María Begoña García Cenador Sandra Pinto Rajeev Gupta Tariq Enver Isidro Sánchez-García Dengli Hong Ricardo Pires das Neves Lino Ferreira
author_facet	Carlos Boto Emanuel Quartin Yijun Cai Alberto Martín-Lorenzo María Begoña García Cenador Sandra Pinto Rajeev Gupta Tariq Enver Isidro Sánchez-García Dengli Hong Ricardo Pires das Neves Lino Ferreira
author_sort	Carlos Boto
title	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_short	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_full	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_fullStr	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_full_unstemmed	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_sort	prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e4bdd43ae19445c3acce605c66e63d91
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Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

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