Metabolomic adaptations and correlates of survival to immune checkpoint blockade

Immune-checkpoint inhibition therapy has achieved success in a subset of patients. Here the authors profiled about 200 relevant metabolites in patient serum samples from three independent immunotherapy trials and found the serum kynurenine/tryptophan ratio increases to be associated with worse overa...

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Autores principales:	Haoxin Li, Kevin Bullock, Carino Gurjao, David Braun, Sachet A. Shukla, Dominick Bossé, Aly-Khan A. Lalani, Shuba Gopal, Chelsea Jin, Christine Horak, Megan Wind-Rotolo, Sabina Signoretti, David F. McDermott, Gordon J. Freeman, Eliezer M. Van Allen, Stuart L. Schreiber, F. Stephen Hodi, William R. Sellers, Levi A. Garraway, Clary B. Clish, Toni K. Choueiri, Marios Giannakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4c8bc25921749a9be4db41b69a5d41b
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spelling	oai:doaj.org-article:e4c8bc25921749a9be4db41b69a5d41b2021-12-02T15:35:31ZMetabolomic adaptations and correlates of survival to immune checkpoint blockade10.1038/s41467-019-12361-92041-1723https://doaj.org/article/e4c8bc25921749a9be4db41b69a5d41b2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12361-9https://doaj.org/toc/2041-1723Immune-checkpoint inhibition therapy has achieved success in a subset of patients. Here the authors profiled about 200 relevant metabolites in patient serum samples from three independent immunotherapy trials and found the serum kynurenine/tryptophan ratio increases to be associated with worse overall survival.Haoxin LiKevin BullockCarino GurjaoDavid BraunSachet A. ShuklaDominick BosséAly-Khan A. LalaniShuba GopalChelsea JinChristine HorakMegan Wind-RotoloSabina SignorettiDavid F. McDermottGordon J. FreemanEliezer M. Van AllenStuart L. SchreiberF. Stephen HodiWilliam R. SellersLevi A. GarrawayClary B. ClishToni K. ChoueiriMarios GiannakisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haoxin Li Kevin Bullock Carino Gurjao David Braun Sachet A. Shukla Dominick Bossé Aly-Khan A. Lalani Shuba Gopal Chelsea Jin Christine Horak Megan Wind-Rotolo Sabina Signoretti David F. McDermott Gordon J. Freeman Eliezer M. Van Allen Stuart L. Schreiber F. Stephen Hodi William R. Sellers Levi A. Garraway Clary B. Clish Toni K. Choueiri Marios Giannakis Metabolomic adaptations and correlates of survival to immune checkpoint blockade
description	Immune-checkpoint inhibition therapy has achieved success in a subset of patients. Here the authors profiled about 200 relevant metabolites in patient serum samples from three independent immunotherapy trials and found the serum kynurenine/tryptophan ratio increases to be associated with worse overall survival.
format	article
author	Haoxin Li Kevin Bullock Carino Gurjao David Braun Sachet A. Shukla Dominick Bossé Aly-Khan A. Lalani Shuba Gopal Chelsea Jin Christine Horak Megan Wind-Rotolo Sabina Signoretti David F. McDermott Gordon J. Freeman Eliezer M. Van Allen Stuart L. Schreiber F. Stephen Hodi William R. Sellers Levi A. Garraway Clary B. Clish Toni K. Choueiri Marios Giannakis
author_facet	Haoxin Li Kevin Bullock Carino Gurjao David Braun Sachet A. Shukla Dominick Bossé Aly-Khan A. Lalani Shuba Gopal Chelsea Jin Christine Horak Megan Wind-Rotolo Sabina Signoretti David F. McDermott Gordon J. Freeman Eliezer M. Van Allen Stuart L. Schreiber F. Stephen Hodi William R. Sellers Levi A. Garraway Clary B. Clish Toni K. Choueiri Marios Giannakis
author_sort	Haoxin Li
title	Metabolomic adaptations and correlates of survival to immune checkpoint blockade
title_short	Metabolomic adaptations and correlates of survival to immune checkpoint blockade
title_full	Metabolomic adaptations and correlates of survival to immune checkpoint blockade
title_fullStr	Metabolomic adaptations and correlates of survival to immune checkpoint blockade
title_full_unstemmed	Metabolomic adaptations and correlates of survival to immune checkpoint blockade
title_sort	metabolomic adaptations and correlates of survival to immune checkpoint blockade
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e4c8bc25921749a9be4db41b69a5d41b
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Metabolomic adaptations and correlates of survival to immune checkpoint blockade

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