Single cell polarity in liquid phase facilitates tumour metastasis
Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity affects attachment, adhesion, transmigration and...
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Nature Portfolio
2018
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oai:doaj.org-article:e4d4ca03df544a909e2ed53aef5fd83a2021-12-02T14:39:08ZSingle cell polarity in liquid phase facilitates tumour metastasis10.1038/s41467-018-03139-62041-1723https://doaj.org/article/e4d4ca03df544a909e2ed53aef5fd83a2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03139-6https://doaj.org/toc/2041-1723Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity affects attachment, adhesion, transmigration and metastasis in vitro and in vivo.Anna LorentzenPaul F. BeckerJan KoslaMassimo SainiKathrin WeidelePaolo RonchiCorinna KleinMonika J. WolfFelix GeistBastian SeubertMarc RingelhanDaniela Mihic-ProbstKnud EsserMarko RoblekFelix KuehneGaia BiancoTracy O’ConnorQuentin MüllerKathleen SchuckSebastian LangeDaniel HartmannSaskia SpaichOlaf GroßJochen UtikalSebastian HaferkampMartin R. SprickAmruta Damle-VartakAlexander HapfelmeierNorbert HüserUlrike ProtzerAndreas TrumppDieter SaurNachiket VartakChristoph A. KleinBernhard PolzerLubor BorsigMathias HeikenwalderNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-20 (2018) |
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DOAJ |
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EN |
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Science Q |
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Science Q Anna Lorentzen Paul F. Becker Jan Kosla Massimo Saini Kathrin Weidele Paolo Ronchi Corinna Klein Monika J. Wolf Felix Geist Bastian Seubert Marc Ringelhan Daniela Mihic-Probst Knud Esser Marko Roblek Felix Kuehne Gaia Bianco Tracy O’Connor Quentin Müller Kathleen Schuck Sebastian Lange Daniel Hartmann Saskia Spaich Olaf Groß Jochen Utikal Sebastian Haferkamp Martin R. Sprick Amruta Damle-Vartak Alexander Hapfelmeier Norbert Hüser Ulrike Protzer Andreas Trumpp Dieter Saur Nachiket Vartak Christoph A. Klein Bernhard Polzer Lubor Borsig Mathias Heikenwalder Single cell polarity in liquid phase facilitates tumour metastasis |
| description |
Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity affects attachment, adhesion, transmigration and metastasis in vitro and in vivo. |
| format |
article |
| author |
Anna Lorentzen Paul F. Becker Jan Kosla Massimo Saini Kathrin Weidele Paolo Ronchi Corinna Klein Monika J. Wolf Felix Geist Bastian Seubert Marc Ringelhan Daniela Mihic-Probst Knud Esser Marko Roblek Felix Kuehne Gaia Bianco Tracy O’Connor Quentin Müller Kathleen Schuck Sebastian Lange Daniel Hartmann Saskia Spaich Olaf Groß Jochen Utikal Sebastian Haferkamp Martin R. Sprick Amruta Damle-Vartak Alexander Hapfelmeier Norbert Hüser Ulrike Protzer Andreas Trumpp Dieter Saur Nachiket Vartak Christoph A. Klein Bernhard Polzer Lubor Borsig Mathias Heikenwalder |
| author_facet |
Anna Lorentzen Paul F. Becker Jan Kosla Massimo Saini Kathrin Weidele Paolo Ronchi Corinna Klein Monika J. Wolf Felix Geist Bastian Seubert Marc Ringelhan Daniela Mihic-Probst Knud Esser Marko Roblek Felix Kuehne Gaia Bianco Tracy O’Connor Quentin Müller Kathleen Schuck Sebastian Lange Daniel Hartmann Saskia Spaich Olaf Groß Jochen Utikal Sebastian Haferkamp Martin R. Sprick Amruta Damle-Vartak Alexander Hapfelmeier Norbert Hüser Ulrike Protzer Andreas Trumpp Dieter Saur Nachiket Vartak Christoph A. Klein Bernhard Polzer Lubor Borsig Mathias Heikenwalder |
| author_sort |
Anna Lorentzen |
| title |
Single cell polarity in liquid phase facilitates tumour metastasis |
| title_short |
Single cell polarity in liquid phase facilitates tumour metastasis |
| title_full |
Single cell polarity in liquid phase facilitates tumour metastasis |
| title_fullStr |
Single cell polarity in liquid phase facilitates tumour metastasis |
| title_full_unstemmed |
Single cell polarity in liquid phase facilitates tumour metastasis |
| title_sort |
single cell polarity in liquid phase facilitates tumour metastasis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/e4d4ca03df544a909e2ed53aef5fd83a |
| work_keys_str_mv |
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