Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence of clonal transformed cells.

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Detalles Bibliográficos
Autores principales: Joe Nassour, Sébastien Martien, Nathalie Martin, Emeric Deruy, Elisa Tomellini, Nicolas Malaquin, Fatima Bouali, Laure Sabatier, Nicolas Wernert, Sébastien Pinte, Eric Gilson, Albin Pourtier, Olivier Pluquet, Corinne Abbadie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/e4ec0071870844e6bdd95abc3f620134
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https://doaj.org/article/e4ec0071870844e6bdd95abc3f620134

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