Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence of clonal transformed cells.

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Autores principales:	Joe Nassour, Sébastien Martien, Nathalie Martin, Emeric Deruy, Elisa Tomellini, Nicolas Malaquin, Fatima Bouali, Laure Sabatier, Nicolas Wernert, Sébastien Pinte, Eric Gilson, Albin Pourtier, Olivier Pluquet, Corinne Abbadie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e4ec0071870844e6bdd95abc3f620134
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spelling	oai:doaj.org-article:e4ec0071870844e6bdd95abc3f6201342021-12-02T15:35:46ZDefective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells10.1038/ncomms103992041-1723https://doaj.org/article/e4ec0071870844e6bdd95abc3f6201342016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10399https://doaj.org/toc/2041-1723It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence of clonal transformed cells.Joe NassourSébastien MartienNathalie MartinEmeric DeruyElisa TomelliniNicolas MalaquinFatima BoualiLaure SabatierNicolas WernertSébastien PinteEric GilsonAlbin PourtierOlivier PluquetCorinne AbbadieNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joe Nassour Sébastien Martien Nathalie Martin Emeric Deruy Elisa Tomellini Nicolas Malaquin Fatima Bouali Laure Sabatier Nicolas Wernert Sébastien Pinte Eric Gilson Albin Pourtier Olivier Pluquet Corinne Abbadie Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
description	It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence of clonal transformed cells.
format	article
author	Joe Nassour Sébastien Martien Nathalie Martin Emeric Deruy Elisa Tomellini Nicolas Malaquin Fatima Bouali Laure Sabatier Nicolas Wernert Sébastien Pinte Eric Gilson Albin Pourtier Olivier Pluquet Corinne Abbadie
author_facet	Joe Nassour Sébastien Martien Nathalie Martin Emeric Deruy Elisa Tomellini Nicolas Malaquin Fatima Bouali Laure Sabatier Nicolas Wernert Sébastien Pinte Eric Gilson Albin Pourtier Olivier Pluquet Corinne Abbadie
author_sort	Joe Nassour
title	Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_short	Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_full	Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_fullStr	Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_full_unstemmed	Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_sort	defective dna single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e4ec0071870844e6bdd95abc3f620134
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Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

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