Optogenetic current in myofibroblasts acutely alters electrophysiology and conduction of co-cultured cardiomyocytes

Abstract Interactions between cardiac myofibroblasts and myocytes may slow conduction and generate spontaneous beating in fibrosis, increasing the chance of life-threatening arrhythmia. While co-culture studies have shown that myofibroblasts can affect cardiomyocyte electrophysiology in vitro, the e...

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Bibliographic Details
Main Authors: Geran M. Kostecki, Yu Shi, Christopher S. Chen, Daniel H. Reich, Emilia Entcheva, Leslie Tung
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
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Online Access:https://doaj.org/article/e51090c71a604ba8a2fb67956066842a
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